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首页> 外文期刊>Advanced Functional Materials >Time-Dependent T_1-T_2 Switchable Magnetic Resonance Imaging Realized by c(RGDyK) Modified Ultrasmall Fe_3O_4 Nanoprobes
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Time-Dependent T_1-T_2 Switchable Magnetic Resonance Imaging Realized by c(RGDyK) Modified Ultrasmall Fe_3O_4 Nanoprobes

机译：c（RGDyK）修饰的超小Fe_3O_4纳米探针实现的时变T_1-T_2磁共振成像

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摘要

To achieve the accurate diagnosis of tumor with the magnetic resonance imaging (MRI), nanomaterials-based contrast agents are developed rapidly. Here, a tumor targeting nanoprobe of c(RGDyK) modified ultrasmall sized iron oxide is reported with high saturation magnetization and high T-1-weighted imaging capability, attributed to a large number of paramagnetic centers on the surface of nanoprobes and rapid water proton exchange rate (inner sphere model), as well as strong superparamagnetism (outer sphere model). These nanoprobes could actively target and gradually accumulate at the tumor site with a time-dependent T-1-T-2 contrast enhancement imaging effect. In in vivo MRI experiments, the nanoprobes exhibit the best T-1 contrast enhancement at 30 min after intravenous administration, followed by gradually vanishing and generating T-2 contrast enhancement with increasing time at tumor site. This is likely due to time-dependent nanoprobes aggregation in tumor, in good agreement with in vitro experiment where aggregated nanoprobes display larger r(2)/r(1) value (19.1) than that of the dispersed nanoprobes (2.8). This dynamic property is completely different from other T-1-T-2 dual-modal nanoprobes which commonly exhibit the T-1- and T-2-weighted enhancement effect at the same time. To sum up, these c(RGDyK) modified ultrasmall Fe3O4 nanoprobes have significant potential to improve the diagnostic accuracy and sensitivity in MRI.%1802281.1-1802281.9
机译：为了通过磁共振成像（MRI）准确诊断肿瘤，基于纳米材料的造影剂得到了快速发展。在这里，据报道，靶向c（RGDyK）修饰的超小型氧化铁的纳米探针具有高饱和磁化强度和高T-1加权成像能力，这归因于纳米探针表面上的大量顺磁中心和快速的质子交换速率（内球模型）以及强超顺磁性（外球模型）。这些纳米探针可以主动靶向并逐渐积累在肿瘤部位，具有时间依赖性的T-1-T-2对比增强成像作用。在体内MRI实验中，纳米探针在静脉内给药后30分钟显示出最佳的T-1对比增强，然后随着肿瘤部位时间的增加逐渐消失并产生T-2对比增强。这可能是由于时间依赖性纳米探针在肿瘤中的聚集所致，这与体外实验非常吻合，在体外实验中，聚集的纳米探针的r（2）/ r（1）值（19.1）比分散的纳米探针（2.8）大。这种动力学性质与其他T-1-T-2双峰纳米探针完全不同，后者通常同时显示T-1-和T-2加权增强作用。综上所述，这些经c（RGDyK）修饰的超小Fe3O4纳米探针具有极大的潜力，可提高MRI的诊断准确性和灵敏度。％1802281.1-1802281.9

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  • 来源
    《Advanced Functional Materials》 |2018年第32期|1802281.1-1802281.9|共9页
  • 作者

    Bai Chen; Jia Zhengyang; Song Lina; Zhang Wei; Chen Yi; Zang Fengchao; Ma Ming; Gu Ning; Zhang Yu;

  • 作者单位

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

    Nanjing Univ Chinese Med, Dept Radiol, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China;

    Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Res Inst Clin Med, Nanjing 210029, Jiangsu, Peoples R China;

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Jiangsu Key Lab Mol & Funct Imaging, Med Sch, Nanjing 210009, Jiangsu, Peoples R China;

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    magnetic resonance imaging; T-1-weighted imaging; T-2-weighted imaging; tumor; ultrasmall Fe3O4 nanoprobes;

    机译：磁共振成像;T-1加权成像;T-2加权成像;肿瘤;超小型Fe3O4纳米探针;

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