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首页> 外文期刊>Advanced Functional Materials >MnO2 Gatekeeper: An Intelligent and O-2-Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2-Sensitive MRI
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MnO2 Gatekeeper: An Intelligent and O-2-Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2-Sensitive MRI

机译：MnO2 Gatekeeper：一种智能的O-2-演化外壳，用于防止高货物有效载荷芯过早释放，克服肿瘤缺氧和酸性H2O2敏感MRI

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摘要

Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal tissues, which inevitably leads to a limited efficacy for photodynamic therapy (PDT) and the enhanced systematic phototoxicity. Moreover, local hypoxia of the tumor tissue also seriously hinders the PDT. To overcome these limitations, an acidic H2O2-responsive and O-2-evolving core-shell PDT nanoplatform is developed by using MnO2 shell as a switchable shield to prevent the premature release of loaded PS in core and elevate the O-2 concentration within tumor tissue. The inner core SiO2-methylene blue obtained by co-condensation has a high PS payload and the outer MnO2 shell shields PS from leaking into blood after intravenous injection until reaching tumor tissue. Moreover, the shell MnO2 simultaneously endows the theranostic nanocomposite with redox activity toward H2O2 in the acidic microenvironment of tumor tissue to generate O-2 and thus overcomes the hypoxia of cancer cells. More importantly, the Mn(II) ion reduced from Mn(IV) is capable of in vivo magnetic resonance imaging selectively in response to overexpressed acidic H2O2. The facile incorporation of the switchable MnO2 shell into one multifunctional diagnostic and therapeutic nanoplatform has great potential for future clinical application.
机译：光敏剂（PS）从纳米载体中过早泄漏会大大减少PS在肿瘤中的蓄积，从而增强正常组织中的非特异性蓄积，这不可避免地导致光动力疗法（PDT）的疗效有限和系统光毒性增强。此外，肿瘤组织的局部缺氧也严重阻碍了PDT。为了克服这些局限性，通过使用MnO2壳作为可切换的屏蔽层来开发酸性H2O2响应和O-2-演化的核-壳PDT纳米平台，以防止核心中负载的PS过早释放并提高肿瘤内的O-2浓度组织。通过共缩合获得的内核SiO2-亚甲基蓝具有较高的PS有效载荷，而MnO2的外壳可防止PS在静脉内注射直至到达肿瘤组织后渗入血液。此外，在肿瘤组织的酸性微环境中，壳MnO2同时赋予血型的纳米复合物以H2O2氧化还原活性，产生O-2，从而克服了癌细胞的缺氧现象。更重要的是，从Mn（IV）还原的Mn（II）离子能够响应于过表达的酸性H2O2选择性进行体内磁共振成像。将可转换的MnO2壳轻松整合到一种多功能的诊断和治疗纳米平台中具有巨大的潜力，可用于未来的临床应用。

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  • 来源
    《Advanced Functional Materials》 |2017年第4期|1604258.1-1604258.12|共12页
  • 作者

    Ma Zhifang; Jia Xiaodan; Bai Jing; Ruan Yudi; Wang Chao; Li Jianming; Zhang Mengchao; Jiang Xiue;

  • 作者单位

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China|Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China;

    Jilin Univ, China Japan Union Hosp, Dept Radiol, Changchun 130022, Jilin, Peoples R China;

    Jilin Univ, China Japan Union Hosp, Dept Radiol, Changchun 130022, Jilin, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    MnO2 shell; MRI; oxygen generation; PDT; premature leakage;

    机译：MnO2壳;MRI;生氧;PDT;过早泄漏;

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