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首页> 外文期刊>Advanced Functional Materials >In Situ Multimodality Imaging of Cancerous Cells Based on a Selective Performance of Fe2+-Adsorbed Zeolitic Imidazolate Framework-8
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In Situ Multimodality Imaging of Cancerous Cells Based on a Selective Performance of Fe2+-Adsorbed Zeolitic Imidazolate Framework-8

机译：基于Fe2 +吸附的沸石咪唑盐Framework-8选择性性能的癌细胞多态性原位成像

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摘要

Metal-organic frameworks possess tremendous potential in biomedical areas for their particular structure. In this study, the authors explored Fe2+-adsorbed nanoscaled zeolitic imidazolate framework-8 (ZIF-8) for in vivo multimodal imaging of cancerous cells for early diagnosis of target cancers. The observations demonstrate that adding Fe2+ into the suspension of ZIF-8 can neutralize the alkalinity and lower toxicity, while the Fe2+-adsorbed ZIF-8 can readily transform to fluorescence ZnO and super paramagnetic Fe3O4 under the synergistic reaction of ROS, GSH, and acids. It is evident that the formation of the nanoclusters ZnO and Fe3O4 only occurred in cancerous cells and does not take place in normal cells, which can be attributed to the different ROS levels and specific micro-environment in tumor and normal cells. This raises the possibility for the Fe2+-adsorbed zeolitic imidazolate frameworks to act as promising agents for the in vivo multimodal imaging of cancers in their early stage.
机译：金属有机骨架由于其特殊的结构在生物医学领域具有巨大的潜力。在这项研究中，作者探索了Fe2 +吸附的纳米级沸石咪唑酸盐骨架8（ZIF-8）用于体内多模态成像癌细胞以早期诊断目标癌症。观察结果表明，在ZIF-8悬浮液中添加Fe2 +可以中和碱度和降低毒性，而在ROS，GSH和酸的协同反应下，吸附Fe2 +的ZIF-8可以轻松转化为荧光ZnO和超顺磁性Fe3O4。 。显然，纳米团簇ZnO和Fe3O4的形成仅在癌细胞中发生，而在正常细胞中不发生，这可以归因于肿瘤细胞和正常细胞中不同的ROS水平和特定的微环境。这增加了Fe2 +吸附的沸石咪唑酸盐骨架在癌症的早期体内多模态成像中用作有希望的药物的可能性。

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  • 来源
    《Advanced Functional Materials》 |2017年第5期|1603926.1-1603926.8|共8页
  • 作者

    Du Tianyu; Zhao Chunqiu; Rehman Fawad Ur; Lai Lanmei; Li Xiaoqi; Sun Yi; Luo Shouhua; Jiang Hui; Gu Ning; Selke Matthias; Wang Xuemei;

  • 作者单位

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Nanjing Foreign Language Sch, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, Lab Signal & Image Proc, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, Lab Signal & Image Proc, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

    Calif State Univ Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90032 USA;

    Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Chien Shiung Wu Lab, Nanjing 210096, Jiangsu, Peoples R China;

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