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Ag/Ag2S Nanocrystals for High Sensitivity Near-Infrared Luminescence Nanothermometry

机译：Ag / Ag2S纳米晶体用于高灵敏度近红外发光测温法

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摘要

Temperature sensing in biological media (cells, tissues, and living organisms) has become essential in the development of the last generation of diagnostics and therapeutic strategies. Thermometry can be used for early detection of different diseases, such as cancer, stroke, or inflammation processes, one of whose incipient symptoms is the appearance of localized temperature singularities. Luminescence nanothermometry, as a tool to accurately provide temperature sensing in biological media, requires the rational design and development of nanothermometers operating in the second biological window. In this work, this is achieved using Ag/Ag2S nanocrystals as multiparametric thermal sensing probes. Temperature sensing with remarkably high sensitivity (4%degrees C-1) is possible through intensity-based measurements, as their infrared emission is strongly quenched by small temperature variations within the biological range (15-50 degrees C). Heating also results in a remarkable redshift of the emission band, which allows for concentrationindependent temperature sensing based on infrared ratiometric measurements, with thermal sensitivity close to 2%degrees C-1. These results make Ag/Ag2S nanocrystals the most sensitive among all noncomposite nanothermometers operating in the second biological window reported so far, allowing for deep-tissue temperature measurements with low uncertainty (0.2 degrees C).
机译：生物介质（细胞，组织和活生物体）中的温度感测在最后一代诊断和治疗策略的开发中已变得至关重要。测温法可用于早期检测不同的疾病，例如癌症，中风或炎症过程，其早期症状之一是出现局部温度异常。发光纳米温度计，作为在生物介质中准确提供温度传感的工具，需要合理设计和开发在第二个生物窗口中运行的纳米温度计。在这项工作中，这是使用Ag / Ag2S纳米晶体作为多参数热传感探针来实现的。通过基于强度的测量，可以以极高的灵敏度（4％摄氏度-1）进行温度感测，因为它们的红外辐射会被生物学范围（15-50摄氏度）内的微小温度变化强烈抑制。加热还会导致发射带发生明显的红移，从而可以基于红外比率测量获得与浓度无关的温度感应，其热灵敏度接近2％摄氏度C-1。这些结果使Ag / Ag2S纳米晶体在迄今为止报道的第二个生物学窗口中运行的所有非复合纳米温度计中最敏感，从而可以进行低不确定性（0.2摄氏度）的深层组织温度测量。

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  • 来源
    《Advanced Functional Materials》 |2017年第6期|1604629.1-1604629.9|共9页
  • 作者

    Ruiz Diego; del Rosal Blanca; Acebron Maria; Palencia Cristina; Sun Chen; Cabanillas-Gonzalez Juan; Lopez-Haro Miguel; Hungria Ana B.; Jaque Daniel; Juarez Beatriz H.;

  • 作者单位

    IMDEA Nanosci, Faraday 9,Campus Cantoblanco, Madrid 28049, Spain;

    Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Mat Phys, Fac Sci, E-28049 Madrid, Spain;

    IMDEA Nanosci, Faraday 9,Campus Cantoblanco, Madrid 28049, Spain|Univ Autonoma Madrid, Fac Sci, Appl Phys Chem Dept, E-28049 Madrid, Spain;

    Univ Hamburg, Inst Phys Chem, Grindelallee 117, D-20146 Hamburg, Germany;

    IMDEA Nanosci, Faraday 9,Campus Cantoblanco, Madrid 28049, Spain;

    IMDEA Nanosci, Faraday 9,Campus Cantoblanco, Madrid 28049, Spain;

    Univ Cadiz, Nanomat & Catalysis Lab, Campus Univ Rio San Pedro S-N, Cadiz 11150, Spain;

    Univ Cadiz, Nanomat & Catalysis Lab, Campus Univ Rio San Pedro S-N, Cadiz 11150, Spain;

    Univ Autonoma Madrid, Fluorescence Imaging Grp, Dept Mat Phys, Fac Sci, E-28049 Madrid, Spain|Hosp Ramon & Cajal, IRYCIS, Madrid 28034, Spain;

    IMDEA Nanosci, Faraday 9,Campus Cantoblanco, Madrid 28049, Spain|Univ Autonoma Madrid, Fac Sci, Appl Phys Chem Dept, E-28049 Madrid, Spain;

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