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首页> 外文期刊>Advanced Functional Materials >A Versatile Plasma Membrane Engineered Cell Vehicle for Contact-Cell-Enhanced Photodynamic Therapy
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A Versatile Plasma Membrane Engineered Cell Vehicle for Contact-Cell-Enhanced Photodynamic Therapy

机译：多功能等离子膜工程细胞载体，用于接触细胞增强的光动力疗法

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摘要

In this paper, a plasma membrane engineering approach is reported for tumor targeting drug delivery and contact-cell-enhanced photodynamic therapy ("CONCEPT") by anchoring functionalized conjugates to cell vehicles. The membrane anchoring conjugates are comprised of a positively charged tetra-arginine peptide sequence, a palmitic-acid-based membrane insertion moiety, and a lysine linker whose e-amine is modified with camptothecin (CPT), protoporphyrin IX (PpIX), or fluorescein (FAM). The amphipathic CPT, PpIX, or FAM conjugates (short as aCPT, aPpIX, or aFAM, respectively) can easily and steadily anchor or coanchor on the cell membrane of RAW264.7 cells (short as RCs), red blood cells, or mesenchymal stem cells. After anchoring aPpIX in RC cells, the tumor targeting ability and therapeutic effect of aPpIX-anchored RC cells (short as aPRCs) is demonstrated in vitro and in vivo. Importantly, aPRCs exhibit the "CONCEPT" effect, which can enhance the therapeutic efficacy and reduce side effects at the single cell level. Due to the good tumor-targeting ability, aPRCs can efficiently inhibit the tumor growth with no systemic toxicity after photoirradiation by photodynamic therapy.
机译：在本文中，通过质膜工程化方法报道了通过将功能化的偶联物锚定到细胞载体上来靶向肿瘤的药物递送和接触细胞增强的光动力疗法（“ CONCEPT”）。膜锚定缀合物由带正电的四精氨酸肽序列，基于棕榈酸的膜插入部分和赖氨酸接头组成，赖氨酸接头的e-胺被喜树碱（CPT），原卟啉IX（PpIX）或荧光素修饰（FAM）。两亲性CPT，PpIX或FAM缀合物（分别简称为aCPT，aPpIX或aFAM）可以轻松，稳定地锚定或锚定在RAW264.7细胞（简称RC），红细胞或间充质干细胞膜上细胞。将aPpIX锚定在RC细胞中后，在体外和体内证明了aPpIX锚定的RC细胞（简称aPRC）的肿瘤靶向能力和治疗效果。重要的是，aPRC表现出“概念”效应，可以增强治疗功效并减少单细胞水平的副作用。由于具有良好的肿瘤靶向能力，aPRC可以有效地抑制肿瘤的生长，并且在通过光动力疗法进行光照射后不会产生全身毒性。

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  • 来源
    《Advanced Functional Materials》 |2017年第12期|1604916.1-1604916.11|共11页
  • 作者

    Li Shi-Ying; Qiu Wen-Xiu; Cheng Hong; Gao Fan; Cao Feng-Yi; Zhang Xian-Zheng;

  • 作者单位

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Dept Chem, Wuhan 430072, Peoples R China|Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China;

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