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首页> 外文期刊>Advanced Functional Materials >Assembly of Au Plasmonic Photothermal Agent and Iron Oxide Nanoparticles on Ultrathin Black Phosphorus for Targeted Photothermal and Photodynamic Cancer Therapy
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Assembly of Au Plasmonic Photothermal Agent and Iron Oxide Nanoparticles on Ultrathin Black Phosphorus for Targeted Photothermal and Photodynamic Cancer Therapy

机译：在超薄黑磷上组装金等离子光热剂和氧化铁纳米粒子，用于靶向光热和光动力癌症治疗

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Photodynamic therapy (PDT), as a minimally invasive and high-efficiency anticancer approach, has received extensive research attention recently. Despite plenty of effort devoted to exploring various types of photodynamic agents with strong near-infrared (NIR) absorbance for PDT and many encouraging progresses achieved in the area, effective and safe photodynamic photosensitizers with good biodegradability and biocompatibility are still highly expected. In this work, a novel nanocomposite has been developed by assembly of iron oxide (Fe3O4) nanoparticles (NPs) and Au nano-particles on black phosphorus sheets (BPs@Au@Fe3O4), which shows a broad light absorption band and a photodegradable character. In vitro and in vivo assay indicates that BPs@Au@Fe3O4 nanoparticles are highly biocompatible and exhibit excellent tumor inhibition efficacy owing to a synergistic photothermal and photodynamic therapy mediated by a low-power NIR laser. Importantly, BPs@Au@Fe3O4 can anticipatorily suppress tumor growth by visualized synergistic therapy with the help of magnetic resonance imaging (MRI). This work presents the first combination application of the photodynamic and photothermal effect deriving from black phosphorus nanosheets and plasmonic photothermal effect from Au nanoparticles together with MRI from Fe3O4 NPs, which may open the new utilization of black phosphorus nanosheets in biomedicine, optoelectronic devices, and photocatalysis.
机译：光动力疗法（PDT）作为一种微创和高效的抗癌方法，最近受到了广泛的研究关注。尽管已投入大量精力来研究各种类型的对PDT具有强近红外（NIR）吸收能力的光动力剂，并且在该领域取得了许多令人鼓舞的进展，但人们仍然对具有良好生物降解性和生物相容性的有效，安全的光动力光敏剂充满期待。在这项工作中，通过将氧化铁（Fe3O4）纳米颗粒（NPs）和金纳米颗粒组装在黑磷片（BPs @ Au @ Fe3O4）上，开发了一种新型的纳米复合材料，该复合材料显示出较宽的光吸收带和可光降解的特性。体外和体内测定表明，由于低功率NIR激光介导的协同光热和光动力疗法，BPs @ Au @ Fe3O4纳米粒子具有高度的生物相容性，并具有出色的肿瘤抑制功效。重要的是，BPs @ Au @ Fe3O4可以借助磁共振成像（MRI）进行可视化协同治疗，从而预期地抑制肿瘤的生长。这项工作提出了黑磷纳米片的光动力和光热效应与金纳米颗粒的等离子光热效应以及Fe3O4 NP的MRI的首次组合应用，这可能会打开黑磷纳米片在生物医学，光电器件和光催化中的新用途。 。

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  • 来源
    《Advanced Functional Materials》 |2017年第18期|1700371.1-1700371.14|共14页
  • 作者

    Yang Dan; Yang Guixin; Yang Piaoping; Lv Ruichan; Gai Shili; Li Chunxia; He Fei; Lin Jun;

  • 作者单位

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China;

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