Spatial Analysis of Metal-PLGA Hybrid Microstructures Using 3D SERS Imaging

Strozyk Malte S.; Jimenez de Aberasturi Dorleta; Gregory Jason V.; Brust Mathias; Lahann Joerg; Liz-Marzan Luis M.

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Spatial Analysis of Metal-PLGA Hybrid Microstructures Using 3D SERS Imaging

机译：使用3D SERS成像对金属PLGA杂化微结构进行空间分析

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The incorporation of gold nanoparticles in biodegradable polymeric nanostructures with controlled shape and size is of interest toward different applications in nanomedicine. Properties of the polymer such as drug loading and antibody functionalization can be combined with the plasmonic properties of gold nanoparticles, to yield advanced hybrid materials. This study presents a new way to synthesize multicompartmental microgels, fibers, or cylinders, with embedded anisotropic gold nanoparticles. Gold nanoparticles dispersed in an organic solvent can be embedded within the poly(lactic-co-glycolic acid) (PLGA) matrix of polymeric microstructures, when prepared via electrohydrodynamic co-jetting. Prior functionalization of the plasmonic nanoparticles with Raman active molecules allows for imaging of the nanocomposites by surface-enhanced Raman scattering (SERS) microscopy, thereby revealing nanoparticle distribution and photostability. These exceptionally stable hybrid materials, when used in combination with 3D SERS microscopy, offer new opportunities for bioimaging, in particular when long-term monitoring is required.

机译：将金纳米颗粒掺入具有可控形状和大小的可生物降解的聚合物纳米结构中，对纳米医学中的不同应用很感兴趣。可以将聚合物的性质（例如载药量和抗体功能化）与金纳米粒子的等离激元性质相结合，以产生高级的杂化材料。这项研究提出了一种新的方法，可以合成具有嵌入式各向异性金纳米粒子的多隔室微凝胶，纤维或圆柱体。当通过电流体共喷射制备时，分散在有机溶剂中的金纳米颗粒可以嵌入聚合物微结构的聚乳酸-乙醇酸共聚物（PLGA）基质中。具有拉曼活性分子的等离子体纳米颗粒的先前功能化允许通过表面增强拉曼散射（SERS）显微镜对纳米复合材料进行成像，从而揭示纳米颗粒的分布和光稳定性。这些异常稳定的混合材料，当与3D SERS显微镜结合使用时，为生物成像提供了新的机会，尤其是在需要长期监控的情况下。

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来源
《Advanced Functional Materials》 |2017年第33期|1701626.1-1701626.7|共7页
作者
Strozyk Malte S.; Jimenez de Aberasturi Dorleta; Gregory Jason V.; Brust Mathias; Lahann Joerg; Liz-Marzan Luis M.;
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作者单位

CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain|Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England;

CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain|CIBER BBN, Donostia San Sebastian 20014, Spain;

Univ Michigan, Dept Chem Engn Mat Sci & Engn, Biointerfaces Inst, Biomed Engn Macromol Sci & Engn, B10-A175 NCRC,2800 Plymouth Rd, Ann Arbor, MI 48109 USA;

Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England;

Univ Michigan, Dept Chem Engn Mat Sci & Engn, Biointerfaces Inst, Biomed Engn Macromol Sci & Engn, B10-A175 NCRC,2800 Plymouth Rd, Ann Arbor, MI 48109 USA;

CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain|CIBER BBN, Donostia San Sebastian 20014, Spain|Ikerbasque, Basque Fdn Sci, Bilbao 48013, Spain;

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正文语种 eng
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关键词
3D surface-enhanced Raman scattering imaging; gold nanostars; PLGA particles; SERS tags;

机译：3D表面增强拉曼散射成像;金纳米星;PLGA颗粒;SERS标签;

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7. Spatial Analysis of Metal-PLGA Hybrid Microstructures Using 3D SERS Imaging [O] . Strozyk MS, de Aberasturi DJ, Gregory JV, 2017

机译：使用3D SERS成像对金属PLGA杂化微结构进行空间分析
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Spatial Analysis of Metal-PLGA Hybrid Microstructures Using 3D SERS Imaging

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