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首页> 外文期刊>Advanced Functional Materials >Scaling Effects on the Electrochemical Stimulation Performance of Au, Pt, and PEDOT:PSS Electrocorticography Arrays
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Scaling Effects on the Electrochemical Stimulation Performance of Au, Pt, and PEDOT:PSS Electrocorticography Arrays

机译：缩放对Au，Pt和PEDOT：PSS电皮层成像阵列的电化学刺激性能的影响

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摘要

The efficacy of electrical brain stimulation in combatting neurodegenerative diseases and initiating function is expected to be significantly enhanced with the development of smaller scale microstimulation electrodes and refined stimulation protocols. These benefits cannot be realized without a thorough understanding of scaling effects on electrochemical charge injection characteristics. This study fabricates and characterizes the electrochemical stimulation capabilities of Au, Pt, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS/Au), and PEDOT:PSS/Pt electrode arrays in the 20-2000 mu m diameter range. This study observes substantial enhancement in charge injection capacity up to 9.5x for PEDOT:PSS microelectrodes compared to metal ones, and 88% lower required power for injecting the same charge density. These significant benefits are strongest for electrode diameters below 200 mu m. Detailed quantitative analyses are provided, enabling optimization of charge injection capacity with potential bias and symmetric and asymmetric pulse width engineering for all diameters. These systematic analyses inform the optimal design for acute and potentially chronic implants in regards to safety and clinically effective stimulation protocols, ensure the longevity of the electrodes below critical electrochemical limits of stimulation, and demonstrate that the material choice and pulse design can lead to more energy efficiency stimulation protocols that are of critical importance for fully implanted devices.
机译：随着较小规模的微刺激电极和完善的刺激方案的发展，预计脑电刺激在对抗神经退行性疾病和启动功能方面的功效将大大增强。如果不全面了解电化学电荷注入特性的缩放效应，就无法实现这些好处。这项研究制造并表征了直径范围为20-2000μm的Au，Pt，聚（3,4-乙撑二氧噻吩）：聚苯乙烯磺酸盐（PEDOT：PSS / Au）和PEDOT：PSS / Pt电极阵列的电化学刺激能力。这项研究发现，与金属电极相比，PEDOT：PSS微电极的电荷注入容量显着提高了9.5倍，并且注入相同电荷密度所需的功率降低了88％。对于直径小于200微米的电极，这些显着优势最为明显。提供了详细的定量分析，可以针对所有直径通过电位偏置以及对称和不对称脉冲宽度工程优化电荷注入能力。这些系统分析为安全性和临床有效的刺激方案提供了针对急性和潜在慢性植入物的最佳设计，确保电极的寿命低于刺激的临界电化学极限，并证明了材料选择和脉冲设计可带来更多的能量效率刺激方案对于完全植入的设备至关重要。

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  • 来源
    《Advanced Functional Materials》 |2017年第42期|1703019.1-1703019.14|共14页
  • 作者

    Ganji Mehran; Tanaka Atsunori; Gilja Vikash; Halgren Eric; Dayeh Shadi A.;

  • 作者单位

    Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA;

    Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA;

    Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA|Univ Calif San Diego, Neurosci Program, La Jolla, CA 92096 USA;

    Univ Calif San Diego, Dept Radiol, La Jolla, CA 92103 USA|Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92103 USA;

    Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA|Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA|Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92103 USA;

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  • 正文语种 eng
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  • 关键词

    neuromodulation; PEDOT:PSS; scaling; size; stimulation;

    机译：神经调节;PEDOT：PSS;结垢;大小;刺激;

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