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首页> 外文期刊>Advanced Functional Materials >Supertough Hybrid Hydrogels Consisting of a Polymer Double-Network and Mesoporous Silica Microrods for Mechanically Stimulated On-Demand Drug Delivery
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Supertough Hybrid Hydrogels Consisting of a Polymer Double-Network and Mesoporous Silica Microrods for Mechanically Stimulated On-Demand Drug Delivery

机译：超韧杂化水凝胶，由聚合物双网络和介孔二氧化硅微棒组成，用于机械刺激的按需药物递送

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摘要

Despite their potential in various fields of bioapplications, such as drug/cell delivery, tissue engineering, and regenerative medicine, hydrogels have often suffered from their weak mechanical properties, which are attributed to their single network of polymers. Here, supertough composite hydrogels are proposed consisting of alginate/polyacrylamide double-network hydrogels embedded with mesoporous silica particles (SBA-15). The supertoughness is derived from efficient energy dissipation through the multiple bondings, such as ionic crosslinking of alginate, covalent crosslinking of polyacrylamide, and van der Waals interactions and hydrogen bondings between SBA-15 and the polymers. The superior mechanical properties of these hybrid hydrogels make it possible to maintain the hydrogel structure for a long period of time in a physiological solution. Based on their high mechanical stability, these hybrid hydrogels are demonstrated to exhibit on-demand drug release, which is controlled by an external mechanical stimulation (both in vitro and in vivo). Moreover, different types of drugs can be separately loaded into the hydrogel network and mesopores of SBA-15 and can be released with different speeds, suggesting that these hydrogels can also be used for multiple drug release.
机译：尽管水凝胶在生物应用的各个领域都具有潜力，例如药物/细胞递送，组织工程和再生医学，但是水凝胶经常因其较弱的机械性能而受苦，这归因于其单一的聚合物网络。在此，提出了由藻酸盐/聚丙烯酰胺双网状水凝胶包埋有中孔二氧化硅颗粒（SBA-15）组成的超韧复合水凝胶。超韧性源自通过多个键的有效能量消散，例如藻酸盐的离子交联，聚丙烯酰胺的共价交联以及SBA-15与聚合物之间的范德华相互作用和氢键。这些杂化水凝胶的优异的机械性能使得可以在生理溶液中长时间维持水凝胶结构。基于它们的高机械稳定性，这些杂化水凝胶被证明表现出按需药物释放，该释放受外部机械刺激（体外和体内）控制。此外，可以将不同类型的药物分别装载到SBA-15的水凝胶网络和中孔中，并且可以不同的速度释放，这表明这些水凝胶也可以用于多种药物释放。

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