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首页> 外文期刊>Advanced Functional Materials >Fluorescent Protein Nanovessels: A New Platform to Generate Bio-Abiotic Hybrid Materials for Bioimaging
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Fluorescent Protein Nanovessels: A New Platform to Generate Bio-Abiotic Hybrid Materials for Bioimaging

机译：荧光蛋白纳米血管：生成用于生物成像的生物非生物混合材料的新平台。

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摘要

In this report, a new platform to generate fluorescent protein nanovessels is described. Based on systemic analyses and reconstitution experiments, a combination of protein scaffold and organic dye is identified. Briefly, certain proteins such as bovine serum albumin (BSA) can rapidly form cube-like scaffold upon heating. This protein scaffolds intrinsically interact with nonfluorescent dyes such as bromophenol blue (BPB), forming BSA-BPB nanocubes (BBNCs). Moreover, it turns out that the commercially available dye BPB contains aggregation-induced emission (AIE) properties, allowing the BBNCs emissive upon irradiation. The fluorescent protein nanovessels are highly biocompatible and can be readily internalized by different type of cells. The fluorescent signal of the materials is well-penetrable from mouse tissues and can be detected at near-infrared region, making it a useful tool for various biological imaging studies. This platform for making fluorescent protein nanovessels is green, rapid, and cost-effective and can be extended to other protein scaffolds and possibly other dye/AIE molecules.
机译：在此报告中，描述了产生荧光蛋白纳米血管的新平台。基于系统分析和重建实验，确定了蛋白质支架和有机染料的组合。简而言之，某些蛋白质（如牛血清白蛋白（BSA））在加热时可以迅速形成立方体状的支架。这种蛋白质支架与非荧光染料如溴酚蓝（BPB）发生内在相互作用，形成BSA-BPB纳米立方体（BBNC）。此外，事实证明，可商购获得的染料BPB包含聚集诱导发射（AIE）特性，允许BBNC在辐射时发射。荧光蛋白纳米血管具有高度的生物相容性，可以容易地被不同类型的细胞内化。该材料的荧光信号可从小鼠组织很好地穿透，并且可以在近红外区域检测到，从而使其成为各种生物成像研究的有用工具。这种用于制造荧光蛋白纳米血管的平台是绿色的，快速的，具有成本效益的，并且可以扩展到其他蛋白支架以及可能的其他染料/ AIE分子。

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  • 来源
    《Advanced Functional Materials》 |2017年第43期|1702051.1-1702051.8|共8页
  • 作者

    Wang Xiaoliang; Zhang Jianxu; Wang Youjun; Liu Yang; Li Zhenhua; Xie Zhigang; Chen Zhijun;

  • 作者单位

    Jilin Univ, Int Joint Res Lab Nanomicro Architecture Chem, Inst Theoret Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China;

    Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China;

    Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China;

    Jilin Univ, Int Joint Res Lab Nanomicro Architecture Chem, Inst Theoret Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China;

    Jilin Univ, Int Joint Res Lab Nanomicro Architecture Chem, Inst Theoret Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    aggregation-induced emission; bio-abiotic hybrids; fluorescent imaging; nonfluorescent dyes; protein nanovessels;

    机译：聚集诱导发射;生物非生物杂合体;荧光成像;非荧光染料;蛋白质纳米血管;

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