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首页> 外文期刊>Advanced Functional Materials >Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer
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Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer

机译：活性氧触发的超快速药物释放和转移性三阴性乳腺癌的局部治疗的治疗学前药囊泡。

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摘要

A reactive oxygen species (ROS)-activatable doxorubicin (Dox) prodrug vesicle (RADV) is presented for image-guided ultrafast drug release and local-regional therapy of the metastatic triple-negative breast cancer (TNBC). RADV is prepared by integrating a ROS-activatable Dox prodrug, a poly(ethylene glycol) (PEG)-modified photosensitizer pyropheophorbide-a, an unsaturated phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine, and cholesterol into one single nanoplatform. RADV is of extremely high drug loading ratio (27.5 wt%) by self-assembly of the phospholipid-mimic Dox prodrug into the liposomal bilayer membrane. RADV displays good colloidal stability to prevent premature drug leakage during the blood circulation and inert photochemotoxicity to avoid nonspecific side effect. RADV passively accumulates at tumor site through the enhanced permeability and retention effect when administrated systemically. Once deposited at the tumor site, RADV generates fluorescent and photoacoustic signals to guide near-infrared (NIR) laser irradiation, which can induce localized ROS generation, not only to trigger prodrug activation and ultrafast drug release but also conduct photodynamic therapy in a spatiotemporally controlled manner. In combination with NIR laser irradiation, RADV efficiently inhibits the tumor growth and distant metastasis of TNBC. Local-regional tumor therapy using intelligent theranostic nanomedicine might provide an alternative option for highly efficient treatment of the metastatic TNBC.
机译：提出了一种活性氧（ROS）激活的阿霉素（Dox）前药囊泡（RADV），用于图像指导的超快药物释放和转移性三阴性乳腺癌（TNBC）的局部治疗。 RADV是通过将ROS激活的Dox前药，聚乙二醇（PEG）改性的光敏剂焦脱镁叶绿酸-a，不饱和磷脂1,2-二油酰基-sn-甘油3-磷酸胆碱和胆固醇整合到一个单一溶液中而制备的纳米平台。 RADV通过将模拟磷脂的Dox前药自组装到脂质体双层膜中而具有极高的药物负载率（27.5 wt％）。 RADV具有良好的胶体稳定性，可防止血液循环中的药物过早泄漏，并具有惰性的光化学毒性，可避免非特异性副作用。全身给药时，RADV通过增强的通透性和保留作用被动地积聚在肿瘤部位。 RADV一旦沉积在肿瘤部位，就会产生荧光和光声信号，以引导近红外（NIR）激光照射，这可以诱导局部ROS生成，不仅可以触发前药活化和超快药物释放，还可以在时空控制下进行光动力疗法方式。结合近红外激光照射，RADV可有效抑制TNBC的肿瘤生长和远处转移。使用智能化治疗性纳米药物的局部区域肿瘤治疗可能为转移性TNBC的高效治疗提供另一种选择。

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  • 来源
    《Advanced Functional Materials》 |2017年第46期|1703674.1-1703674.12|共12页
  • 作者

    Zhou Fangyuan; Feng Bing; Wang Tingting; Wang Dangge; Cui Zhirui; Wang Siling; Ding Chunyong; Zhang Zhiwen; Liu Jian; Yu Haijun; Li Yaping;

  • 作者单位

    Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;

    Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

    Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China|Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China|Univ Chinese Acad Sci, Beijing 100049, Peoples R China;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    cancer theranostics; local-regional therapy; prodrug vesicles; reactive oxygen species; triple-negative breast cancer;

    机译：癌症治疗学;局部治疗;前药囊泡;活性氧;三阴性乳腺癌;

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