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首页> 外文期刊>Advanced Functional Materials >Methods and Applications of Multilayer Silk Fibroin Laminates Based on Spatially Controlled Welding in Protein Films
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Methods and Applications of Multilayer Silk Fibroin Laminates Based on Spatially Controlled Welding in Protein Films

机译：基于蛋白质膜空间控制焊接的多层丝素蛋白层压板的方法和应用

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摘要

Recent use of biopolymers as interface materials between planar, inorganic electronics and biological tissues has required the adaptation of micro-and nanofabrication techniques for use with these nontraditional materials. In this work, a method which builds on this principle for spatial control of adhesion in multilayer silk fibroin laminates is investigated. This is accomplished through the addition of a spatially patterned amorphous silk adhesive layer in between the films to be adhered, before thermally processing them with heat (120 degrees C) and pressure (80 Psi) according to established procedures. A one-step method for rapid, high-throughput fabrication is demonstrated, which establishes a strong (1100 kPa) bond between the layers independent of the initial processing conditions of the films. The adhesive layers can be patterned using existing silk fabrication techniques, allowing for the assembly of complex geometries including bilayers and microbubbles. Additionally, the utility of this method is demonstrated for potential applications in drug delivery and transient electronics. This approach provides a versatile method for construction of complex multilayer structures in silk, which with future work may ultimately improve the utility of this material as a bridge between high technology and the biomedical sciences.
机译：生物聚合物作为平面，无机电子器件和生物组织之间的界面材料的最新使用要求对微和纳米加工技术进行改造，以与这些非传统材料一起使用。在这项工作中，研究了以此原理为基础的多层丝素蛋白层压板的空间粘合控制方法。这是通过在要粘合的薄膜之间添加空间图案化的非晶形丝绸粘合层来实现的，然后根据既定程序在加热（120摄氏度）和压力（80 Psi）的条件下对其进行热处理。演示了一种用于快速，高通量制造的一步方法，该方法在层之间建立了牢固的（1100 kPa）键，而与薄膜的初始加工条件无关。可以使用现有的丝制造技术来对粘合剂层进行构图，从而允许组装包括双层和微气泡在内的复杂几何形状。此外，该方法的实用性已被证明可用于药物输送和瞬态电子学中。这种方法为在丝绸中构造复杂的多层结构提供了一种通用的方法，随着未来的工作，该方法最终可以提高这种材料作为高科技与生物医学之间的桥梁的实用性。

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