Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection

Wang Fei; Fang Ronnie H.; Luk Brian T.; Hu Che-Ming J.; Thamphiwatana Soracha; Dehaini Diana; Angsantikul Pavimol; Kroll Ashley V.; Pang Zhiqing; Gao Weiwei; Lu Weiyue; Zhang Liangfang

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Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection

机译：基于纳米颗粒的抗毒力疫苗，用于耐甲氧西林金黄色葡萄球菌皮肤感染的管理

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With the rising threat of antibiotic-resistant bacteria, vaccination is becoming an increasingly important strategy to prevent and manage bacterial infections. Made from deactivated bacterial toxins, toxoid vaccines are widely used in the clinic as they help to combat the virulence mechanisms employed by different pathogens. Here, the efficacy of a biomimetic nanoparticle-based antivirulence vaccine is examined in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection. Vaccination with nanoparticle-detained staphylococcal a-hemolysin (Hla) effectively triggers the formation of germinal centers and induces high anti-Hla titers. Compared to mice vaccinated with control samples, those vaccinated with the nanoparticle toxoid show superior protective immunity against MRSA skin infection. The vaccination not only inhibits lesion formation at the site of bacterial challenge but also reduces the invasiveness of MRSA, preventing dissemination into other organs. Overall, this biomimetic nanoparticle-based toxin detainment strategy is a promising method for the design of potent antivirulence vaccines for managing bacterial infections.

机译：随着抗生素抗性细菌威胁的增加，疫苗接种已成为预防和管理细菌感染的越来越重要的策略。类毒素疫苗由失活的细菌毒素制成，可帮助对抗不同病原体采用的毒力机制，因此在临床上得到广泛使用。在此，在耐甲氧西林的金黄色葡萄球菌（MRSA）皮肤感染的小鼠模型中检查了基于仿生纳米颗粒的抗毒力疫苗的功效。用纳米颗粒保留的葡萄球菌α-溶血素（Hla）进行疫苗接种可有效触发生发中心的形成，并诱导高抗Hla滴度。与接种对照样品的小鼠相比，接种纳米颗粒类毒素的小鼠对MRSA皮肤感染显示出优异的保护性免疫力。接种疫苗不仅抑制了细菌攻击部位的病变形成，而且降低了MRSA的侵袭性，从而阻止了其扩散到其他器官中。总的来说，这种基于仿生纳米颗粒的毒素滞留策略是用于设计有效的抗毒力疫苗以管理细菌感染的有前途的方法。

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来源
《Advanced Functional Materials》 |2016年第10期|1628-1635|共8页
作者
Wang Fei; Fang Ronnie H.; Luk Brian T.; Hu Che-Ming J.; Thamphiwatana Soracha; Dehaini Diana; Angsantikul Pavimol; Kroll Ashley V.; Pang Zhiqing; Gao Weiwei; Lu Weiyue; Zhang Liangfang;
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Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA|Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China|Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA|Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA|Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China|Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China|Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China;

Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA|Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;

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1. Redeploying beta-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections [J] . Waters Elaine M., Rudkin Justine K., Coughlan Simone, The Journal of Infectious Diseases . 2017,第1期

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2. European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid [J] . M. Bassetti, M. Baguneid, E. Bouza, Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2014,第Suppla4期

机译：欧洲的观点和最新经验，对利奈唑胺具有十多年经验的耐甲氧西林金黄色葡萄球菌引起的复杂皮肤和软组织感染的管理
3. Outpatient management of skin and soft tissue infections associated with community-associated methicillin-resistant staphylococcus aureus: An evidence-based approach [J] . SeeleangK., SaksM., WinsteadY. The journal for nurse practitioners: JNP . 2013,第9期

机译：与社区相关的耐甲氧西林金黄色葡萄球菌相关的皮肤和软组织感染的门诊管理：循证方法
4. THE EMERGENCE OF A BAD BUG: TREATMENT, INFECTION CONTROL PUBLIC HEALTH CHALLENGES OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) [C] . Jeffrey B. Bender Canadian Veterinary Medical Association Convention . 2009

机译：出现坏虫子：耐甲氧西林金黄色葡萄球菌的治疗，感染控制和公共卫生挑战（MRSA）
5. Chiropractic Student Infection Control Practices and Methicillin-Resistant Staphylococcus aureus Skin Infections. [D] . Egan, Jonathon Todd. 2016

机译：捏脊学生感染控制措施和耐甲氧西林金黄色葡萄球菌皮肤感染。
6. Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection [O] . Fei Wang, Dr. Ronnie H. Fang, Brian T. Luk, -1

机译：基于纳米颗粒的抗毒力疫苗用于耐甲氧西林金黄色葡萄球菌皮肤感染的管理
7. Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings [O] . G. C. LEE, R. G. HALL, N. K. BOYD, 2016

机译：社区相关的葡萄球菌的预测因子，耐甲氧西林和甲氧西林易感金黄色葡萄球菌皮肤和初级保健环境中的软组织感染

Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection

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