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首页> 外文期刊>Advanced Functional Materials >FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free Cu-64-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy
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FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free Cu-64-Labeling and Multimodal Image-Guided Photothermal-Radiation Therapy

机译：通过阳离子交换制备的FeSe2装饰的Bi2Se3纳米片，用于无螯合剂的Cu-64标签和多峰图像引导的光热辐射疗法

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摘要

Multifunctional theranostic agents have become rather attractive to realize image-guided combination cancer therapy. Herein, a novel method is developed to synthesize Bi2Se3 nanosheets decorated with mono-dispersed FeSe2 nanoparticles (FeSe2/Bi2Se3) for tetra-modal image-guided combined photothermal and radiation tumor therapy. Interestingly, upon addition of Bi(NO3)(3), pre-made FeSe2 nanoparticles via cation exchange would be gradually converted into Bi2Se3 nanosheets, on which remaining FeSe2 nanoparticles are decorated. The yielded FeSe2/Bi2Se3 composite-nanostructures are then modified with polyethylene glycol (PEG). Taking advantages of the high r(2) relaxivity of FeSe2, the X-ray attenuation ability of Bi2Se3, the strong near-infrared optical absorbance of the whole nanostructure, as well as the chelate-free radiolabeling of Cu-64 on FeSe2/Bi2Se3-PEG, in vivo magnetic resonance/computer tomography/photoacoustic/position emission tomography multimodal imaging is carried out, revealing efficient tumor homing of FeSe2/Bi2Se3-PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe2/Bi2Se3-PEG, in vivo photothermal and radiation therapy to achieve synergistic tumor destruction is then realized, without causing obvious toxicity to the treated animals. This work presents a unique method to synthesize composite-nanostructures with highly integrated functionalities, promising not only for nano-biomedicine but also potentially for other different nanotechnology fields.
机译：多功能治疗试剂已经变得相当有吸引力，可以实现图像引导的联合癌症治疗。本文中，开发了一种新颖的方法来合成由单分散FeSe2纳米颗粒（FeSe2 / Bi2Se3）装饰的Bi2Se3纳米片，用于四峰图像引导的光热和放射肿瘤联合治疗。有趣的是，在添加Bi（NO3）（3）后，预制的FeSe2纳米颗粒通过阳离子交换将逐渐转化为Bi2Se3纳米片，并在其上装饰剩余的FeSe2纳米颗粒。然后用聚乙二醇（PEG）修饰所得的FeSe2 / Bi2Se3复合纳米结构。利用FeSe2的高r（2）弛豫性，Bi2Se3的X射线衰减能力，整个纳米结构的强近红外光吸收以及FeSe2 / Bi2Se3上Cu-64的无螯合放射性标记-PEG，体内磁共振/计算机断层扫描/光声/位置发射断层扫描进行了多模态成像，揭示了静脉注射后FeSe2 / Bi2Se3-PEG的有效肿瘤归巢。利用FeSe2 / Bi2Se3-PEG的内在物理特性，可以实现体内光热和放射治疗以实现协同的肿瘤破坏，而不会对治疗的动物造成明显的毒性。这项工作提出了一种独特的方法来合成具有高度集成功能的复合纳米结构，不仅有望用于纳米生物医学，而且有望用于其他不同的纳米技术领域。

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  • 来源
    《Advanced Functional Materials》 |2016年第13期|2185-2197|共13页
  • 作者

    Cheng Liang; Shen Sida; Shi Sixiang; Yi Yuan; Wang Xiaoyong; Song Guosheng; Yang Kai; Liu Gang; Barnhart Todd E.; Cai Weibo; Liu Zhuang;

  • 作者单位

    Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA;

    Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

    Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA;

    Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Jiangsu Prov Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China;

    Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361005, Fujian, Peoples R China;

    Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Jiangsu Prov Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China;

    Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361005, Fujian, Peoples R China;

    Univ Wisconsin, Dept Med Phys, 1530 Med Sci Ctr, Madison, WI 53706 USA;

    Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA|Univ Wisconsin, Mat Sci Program, Madison, WI 53706 USA;

    Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    cation exchange; chelator-free radiolabeling; FeSe2; Bi2Se3 nanostructures; multimodal imaging; photothermal-radiation therapy treatment;

    机译：阳离子交换;无螯合放射性标记;FeSe2;Bi2Se3纳米结构;多峰成像;光热辐射治疗;

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