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首页> 外文期刊>Advanced Functional Materials >Two are Better than One: Combining ZnO and MgF2 Nanoparticles Reduces Streptococcus pneumoniae and Staphylococcus aureus Biofilm Formation on Cochlear Implants
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Two are Better than One: Combining ZnO and MgF2 Nanoparticles Reduces Streptococcus pneumoniae and Staphylococcus aureus Biofilm Formation on Cochlear Implants

机译：两种优于一种：结合ZnO和MgF2纳米颗粒可减少人工耳蜗上的肺炎链球菌和金黄色葡萄球菌生物膜形成

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摘要

Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S.aureus) are considered the most common colonizers of cochlear implants (CI), which have prompted the search for new ways to inhibit their growth and biofilm development. In the current study, CI-based platforms are prepared and sonochemically coated with ZnO or MgF2 nanoparticles (NPs), two agents previously shown to possess antibacterial properties. Additionally, a method is developed for coating both ZnO and MgF2 on the same platform to achieve synergistic activity against both pathogens. Each surface is characterized, and the optimal conditions for the NP homogenous distribution on the surface are determined. The ZnO-MgF2 surface significantly reduces the S. pneumoniae and S. aureus biofilm compared with the surfaces coated with either ZnO or MgF2, even though it contains smaller amounts of each NP type. Importantly, leaching assays show that the NPs remain anchored to the surface for at least 7 d. Finally, biocompatibility studies demonstrate that coating with low concentrations of ZnO-MgF2 results in no toxicity toward primary human fibroblasts from the auditory canal. Taken together, these findings underscore the potential of using NP combinations such as the one presented here to efficiently inhibit bacterial colonization and growth on medical devices such as CIs.
机译：肺炎链球菌（S. pneumoniae）和金黄色葡萄球菌（S.aureus）被认为是人工耳蜗（CI）的最常见定居者，这促使人们寻求抑制其生长和生物膜发育的新方法。在当前的研究中，准备了基于CI的平台，并用ZnO或MgF2纳米粒子（NPs）进行声化学涂覆，这两种试剂先前已显示具有抗菌性能。此外，开发了一种在同一平台上同时涂覆ZnO和MgF2以获得对两种病原体的协同活性的方法。表征每个表面，并确定该表面上NP均匀分布的最佳条件。与ZnO或MgF2覆盖的表面相比，ZnO-MgF2表面显着减少了肺炎链球菌和金黄色葡萄球菌的生物膜，即使每种NP类型的含量较小。重要的是，浸出试验表明，NP至少在7 d内保持锚固在表面。最后，生物相容性研究表明，低浓度的ZnO-MgF2涂层不会对来自听道的人类原代成纤维细胞产生毒性。综上所述，这些发现强调了使用NP组合（如此处介绍的组合）有效抑制细菌定植和在诸如CI的医疗设备上生长的潜力。

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  • 来源
    《Advanced Functional Materials》 |2016年第15期|2473-2481|共9页
  • 作者

    Natan Michal; Edin Fredrik; Perkas Nina; Yacobi Gila; Perelshtein Ilana; Segal Elad; Homsy Alexandra; Laux Edith; Keppner Herbert; Rask-Andersen Helge; Gedanken Aharon; Banin Ehud;

  • 作者单位

    Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel;

    Univ Uppsala Hosp, Dept Surg Sci, Otolaryngol Sect, SE-75185 Uppsala, Sweden;

    Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel;

    Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel;

    Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel;

    Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel;

    Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland;

    Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland;

    Univ Appl Sci Western Switzerland, Haute Ecole Arc Ingn, HES SO, Eplatures Grise 17, CH-2300 La Chaux De Fonds, Switzerland;

    Univ Uppsala Hosp, Dept Surg Sci, Otolaryngol Sect, SE-75185 Uppsala, Sweden;

    Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel;

    Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel|Bar Ilan Univ, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel;

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  • 正文语种 eng
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  • 关键词

    antibiofilm; bacteria; cochlear; implants; nanoparticles;

    机译：抗生物膜;细菌;耳蜗;植入物;纳米颗粒;

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