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Well-Defined Protein-Based Supramolecular Nanoparticles with Excellent MRI Abilities for Multifunctional Delivery Systems

机译：良好定义的基于蛋白质的超分子纳米粒子，具有出色的MRI能力，可用于多功能递送系统

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摘要

Protein-based nanoparticles are widely used for effective biomedical applications. The objective of this work is to design series of magnetic resonance imaging (MRI)-visible cationic supramolecular nanoparticles (PGEA@BSA-Ad/Gd3+) based on bovine serum albumin (BSA) and beta-cyclodextrin-cored star ethanolamine-functionalized poly(glycidyl methacrylate) (CD-PGEA) in the presence of Gd3+ ions for multifunctional delivery systems. CD-PGEA is prepared via atom transfer radical polymerization and ring-opening reaction. It is found that in the absence of Gd3+ ions, CD-PGEA does not well interact with adamantine-modified BSA (BSA-Ad). The well-defined PGEA@BSA-Ad/Gd3+ supramolecular nanoparticles could be produced through the synergistic actions of the host-guest and electrostatic self-assemblies by mixing aqueous solutions of CD-PGEA, BSA-Ad, and Gd3+. In comparison with CD-PGEA assembly units, such kinds of uniform PGEA@ BSA-Ad/Gd3+ supramolecular nanoparticles exhibit better pDNA condensation ability, lower cytotoxicity, higher gene transfection, and easier cellular uptake. In addition, PGEA@ BSA-Ad/Gd3+ also produces outstanding MRI abilities, much better than Magnevist (Gd-diethylenetriaminepentacetate acid). The present design of protein-polymer supramolecular nanoparticles with MRI contrast agents would provide a new way for multifunctional gene/drug delivery systems.
机译：基于蛋白质的纳米颗粒被广泛用于有效的生物医学应用。这项工作的目的是设计基于牛血清白蛋白（BSA）和以β-环糊精为核心的星形乙醇胺官能化的聚核磁共振成像（MRI）-可见的阳离子超分子纳米粒子（PGEA @ BSA-Ad / Gd3 +）系列。 Gd3 +离子存在下的甲基丙烯酸缩水甘油酯（CD-PGEA），用于多功能递送系统。 CD-PGEA通过原子转移自由基聚合和开环反应制备。发现在不存在Gd3 +离子的情况下，CD-PGEA与金刚烷修饰的BSA（BSA-Ad）不能很好地相互作用。定义明确的PGEA @ BSA-Ad / Gd3 +超分子纳米粒子可以通过混合CD-PGEA，BSA-Ad和Gd3 +的水溶液，通过客体和静电自组装的协同作用产生。与CD-PGEA组装单元相比，此类均匀的PGEA @ BSA-Ad / Gd3 +超分子纳米颗粒具有更好的pDNA凝聚能力，更低的细胞毒性，更高的基因转染和更容易的细胞摄取。此外，PGEA @ BSA-Ad / Gd3 +还具有出色的MRI能力，比Magnevist（Gd-二亚乙基三胺五乙酸酯）要好得多。具有MRI造影剂的蛋白质-聚合物超分子纳米颗粒的当前设计将为多功能基因/药物递送系统提供新途径。

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  • 来源
    《Advanced Functional Materials》 |2016年第17期|2855-2865|共11页
  • 作者

    Yuan Huimin; Xu Chen; Zhao Yu; Yu Bingran; Cheng Gang; Xu Fu-Jian;

  • 作者单位

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China;

    Univ Akron, Dept Chem & Biomol Engn, Akron, OH 44325 USA;

    Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China|Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China;

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