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首页> 外文期刊>Advanced Functional Materials >Light-Responsive, Singlet-Oxygen-Triggered On-Demand Drug Release from Photosensitizer-Doped Mesoporous Silica Nanorods for Cancer Combination Therapy
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Light-Responsive, Singlet-Oxygen-Triggered On-Demand Drug Release from Photosensitizer-Doped Mesoporous Silica Nanorods for Cancer Combination Therapy

机译：从光敏剂掺杂的介孔二氧化硅纳米棒中获得光响应性，单线态氧触发的按需药物释放，以用于癌症联合治疗。

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摘要

Smart drug delivery systems with on-demand drug release capability are rather attractive to realize highly specific cancer treatment. Herein, a novel light-responsive drug delivery platform based on photosensitizer chlorin e6 (Ce6) doped mesoporous silica nanorods (CMSNRs) is developed for on-demand light-triggered drug release. In this design, CMSNRs are coated with bovine serum albumin (BSA) via a singlet oxygen (SO)-sensitive bis-(alkylthio) alkene (BATA) linker, and then modified with polyethylene glycol (PEG). The obtained CMSNR-BATA-BSA-PEG, namely CMSNR-B-PEG, could act as a drug delivery carrier to load with either small drug molecules such as doxorubicin (DOX), or larger macromolecules such as cis-Pt (IV) pre-drug conjugated third generation dendrimer (G3-Pt), both of which are sealed inside the mesoporous structure of nanorods by BSA coating. Upon 660 nm light irradiation with a rather low power density, CMSNRs with intrinsic Ce6 doping would generate SO to cleave BATA linker, inducing detachment of BSA-PEG from the nanorod surface and thus triggering release of loaded DOX or G3-Pt. As evidenced by both in vitro and in vivo experiments, such CMSNR-B-PEG with either DOX or G3-Pt loading offers remarkable synergistic therapeutic effects in cancer treatment, owing to the on-demand release of therapeutics specifically in the tumor under light irradiation.
机译：具有按需药物释放功能的智能药物输送系统对于实现高度特异性的癌症治疗颇具吸引力。本文中，开发了一种基于光敏剂二氢卟酚e6（Ce6）掺杂的中孔二氧化硅纳米棒（CMSNRs）的新型光响应药物传递平台，用于按需触发光释放药物。在此设计中，CMSNRs通过单线态氧（SO）敏感的双-（烷硫基）烯烃（BATA）接头涂有牛血清白蛋白（BSA），然后用聚乙二醇（PEG）修饰。所获得的CMSNR-BATA-BSA-PEG，即CMSNR-B-PEG，可以充当载药载体，以载有小药物分子（如阿霉素（DOX））或较大的大分子（如顺铂（IV）） -药物共轭第三代树状聚合物（G3-Pt），两者均通过BSA涂层密封在纳米棒的介孔结构内部。在以相当低的功率密度照射660 nm的光后，具有固有Ce6掺杂的CMSNRs将产生SO来裂解BATA接头，从而导致BSA-PEG从纳米棒表面脱离，从而触发负载的DOX或G3-Pt的释放。正如体外和体内实验所证明的那样，这种具有DOX或G3-Pt载量的CMSNR-B-PEG在癌症治疗中提供了显着的协同治疗效果，这是由于在光照射下按需释放治疗剂，特别是在肿瘤中。

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  • 来源
    《Advanced Functional Materials》 |2016年第26期|4722-4732|共11页
  • 作者

    Yang Guangbao; Sun Xiaoqi; Liu Jingjing; Feng Liangzhu; Liu Zhuang;

  • 作者单位

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;

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