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首页> 外文期刊>Advanced Functional Materials >Thermoresponsive Nanogel-Encapsulated PEDOT and HSP70 Inhibitor for Improving the Depth of the Photothermal Therapeutic Effect
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Thermoresponsive Nanogel-Encapsulated PEDOT and HSP70 Inhibitor for Improving the Depth of the Photothermal Therapeutic Effect

机译：热响应性纳米凝胶包封的PEDOT和HSP70抑制剂可改善光热治疗效果的深度

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摘要

Photothermal therapy (PTT), a new, noninvasive treatment measure, has recently drawn much attention. However, due to the limited penetration depth of near-infrared (NIR) light, PTT is focused on treating superficial tumors. Improving the depth of the therapeutic effect is a bottleneck for successful PTT. To solve this problem, a new kind of nanoplatform (Nanogel+phenylethynesulfonamide (PES)) is fabricated by using a thermo-responsive polymer shell (poly(N-isopropylacrylamide-co-acrylic acid) to encapsulate 2-PES, an effective heat shock protein 70 (HSP70) inhibitor, and poly(3,4-ethylenedioxythiophene), a widely used photothermal coupling agent. Upon NIR irradiation, PES can be released from the Nanogel+PES when a thermo-responsive phase transition occurs, which could restrain the function of HSP70 and reduces the cells' endurance to heat. In this way, a better therapeutic effect on deeper tissues is achieved with a relatively small rise in temperature. Therefore, with the advantages of the thermo-responsive photothermal effect, coupled with the inhibition of HSP70, and minimal cytotoxicity, the Nanogel+PES appears to be a promising photothermal agent that can improve the depth of the PTT effect.
机译：光热疗法（PTT）是一种新的无创治疗手段，最近引起了广泛关注。但是，由于近红外（NIR）光的穿透深度有限，因此PTT专注于治疗浅表肿瘤。提高治疗效果的深度是成功进行PTT的瓶颈。为解决这一问题，利用热响应性聚合物壳（聚（N-异丙基丙烯酰胺-共丙烯酸））包裹2-PES，形成了一种新型的纳米平台（Nanogel +苯基乙炔磺酰胺（PES）），有效的热冲击。蛋白70（HSP70）抑制剂和聚（3,4-乙撑二氧噻吩），一种广泛使用的光热偶合剂，在近红外辐射下，当发生热响应相变时，PES可以从纳米凝胶+ PES中释放出来，这可能抑制了HSP70的功能，降低了细胞对热的耐受性，从而以相对较小的温度升高实现了对较深组织的更好的治疗效果，因此，具有热响应光热效应和抑制作用的优势由于HSP70具有HSP70的优点，并且具有最小的细胞毒性，因此Nanogel + PES似乎是一种有前途的光热剂，可以改善PTT效应的深度。

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  • 来源
    《Advanced Functional Materials》 |2016年第26期|4749-4759|共11页
  • 作者

    Liu Dongdong; Ma Liyi; An Yanxin; Li Yu; Liu Yuxin; Wang Lu; Guo Jin; Wang Jianhua; Zhou Jing;

  • 作者单位

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

    Capital Inst Pediat, Beijing Municipal Key Lab Child Dev & Nutri, Dept Biotechnol, Beijing 100020, Peoples R China;

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

    Capital Inst Pediat, Beijing Municipal Key Lab Child Dev & Nutri, Dept Biotechnol, Beijing 100020, Peoples R China;

    Capital Inst Pediat, Beijing Municipal Key Lab Child Dev & Nutri, Dept Biotechnol, Beijing 100020, Peoples R China;

    Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China;

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