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首页> 外文期刊>Advanced Functional Materials >Highly Emissive Nd3+-Sensitized Multilayered Upconversion Nanoparticles for Efficient 795 nm Operated Photodynamic Therapy
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Highly Emissive Nd3+-Sensitized Multilayered Upconversion Nanoparticles for Efficient 795 nm Operated Photodynamic Therapy

机译：高发射率的Nd3 +敏感的多层上转换纳米颗粒，可有效进行795 nm的光动力疗法

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摘要

Photodynamic therapy (PDT) is a noninvasive and site-specific therapeutic technique for the clinical treatment of various of superficial diseases. In order to tuning the operation wavelength and improve the tissue penetration of PDT, rare-earth doped upconversion nanoparticles (UCNPs) with strong anti-stokes emission are introduced in PDT recently. However, the conventional Yb3+-sensitized UCNPs are excited at 980 nm which is over-lapped with the absorption of water, thus resulting in strong overheating effect. Herein, a convenient but effective design to obtain highly emissive 795 nm excited Nd3+-sensitized UCNPs (NaYF4:Yb, Er@NaYF4:Yb0.1Nd0.4@NaYF4) is reported, which provides about six times enhanced upconversion luminescence, comparing with traditional UCNPs (NaYF4:Yb, Er@NaYF4). A colloidal stable and non-leaking PDT nanoplatform is fabricated later through a highly PEGylated mesoporous silica layer with covalently linked photosensitizer (Rose Bengal derivative). With as-prepared Nd3+-sensitized UCNPs, the nanoplatform can produce singlet oxygen more effective than traditional UCNPs. Significant higher penetration depth and lower overheating are demonstrated as well. All these features make as-prepared nanocomposites excellent platform for PDT treatment. In addition, the nanoplatform with uniform size, high surface area, and excellent colloidal stability can be extended for other biomedical applications, such as imaging probes, biosensors, and drug delivery vehicles.
机译：光动力疗法（PDT）是一种用于临床治疗各种浅表疾病的非侵入性且针对特定地点的治疗技术。为了调整PDT的工作波长并提高其组织渗透性，最近在PDT中引入了具有强抗焦炭发射的稀土掺杂上转换纳米粒子（UCNPs）。然而，传统的Yb3 +增敏的UCNPs在980 nm处被激发，吸收了水分，因此重叠，从而导致强烈的过热效应。本文报道了一种方便但有效的设计，可获得高发射率的795 nm激发的Nd3 +敏化的UCNP（NaYF4：Yb，Er @ NaYF4：Yb0.1Nd0.4@NaYF4），与传统方法相比，其上转换发光增强了约六倍。 UCNP（NaYF4：Yb，Er @ NaYF4）。胶体稳定且不渗漏的PDT纳米平台随后通过带有共价连接的光敏剂（Rose Bengal衍生物）的高度PEG化的介孔二氧化硅层制成。使用制备好的Nd3 +敏化UCNP，纳米平台可以产生比传统UCNP更有效的单线态氧。还显示出明显更高的熔深和更低的过热度。所有这些功能使所制备的纳米复合材料成为用于PDT处理的出色平台。另外，具有均一尺寸，高表面积和优异胶体稳定性的纳米平台可以扩展到其他生物医学应用，例如成像探针，生物传感器和药物输送载体。

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  • 来源
    《Advanced Functional Materials》 |2016年第26期|4778-4785|共8页
  • 作者

    Lu Feng; Yang Lin; Ding Yujie; Zhu Jun-Jie;

  • 作者单位

    Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China|Nanjing Univ Posts & Telecommun, Inst Adv Mat, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China;

    Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China|Anhui Polytech Univ, Coll Biochem Engn, Wuhu 241000, Peoples R China;

    Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China;

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