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Metal-Organic-Framework-Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response

机译：基于金属有机框架的疫苗平台，可增强系统的免疫和记忆反应

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摘要

Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. However, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen-specific cytotoxic T-lymphocyte responses. This study demonstrates for the first time the construction of metal-organic-framework (MOF) based vaccines by encapsulating ovalbumin (OVA) and attaching the cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) in/on zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. The pH responsive decomposition feature enables the system to release the protein antigens and CpG ODNs in the same antigen presenting cells more efficiently. More importantly, in addition to the induction of a potent immune memory response, both in vitro and in vivo experiments show that the vaccines can induce strong humoral and cellular immunity. These findings suggest that the MOF-based vaccine platforms can be used to produce effective vaccines against a range of ailments, which will facilitate the application of MOFs in biomedical areas.
机译：纳米颗粒递送平台已在许多方面显示了疫苗的有希望的优势。然而，迄今为止，它们的应用受到冗长的合成方案，抗原特异性修饰的要求以及诱导抗原特异性细胞毒性T淋巴细胞反应的低效率的限制。这项研究首次证明了通过包裹卵清蛋白（OVA）并将胞嘧啶-磷酸-鸟嘌呤寡脱氧核苷酸（CpG ODN）附着在沸石咪唑盐构架8（ZIF- 8）纳米粒子。 pH响应分解功能使系统能够更有效地释放相同抗原呈递细胞中的蛋白质抗原和CpG ODN。更重要的是，除了诱导有效的免疫记忆反应外，体外和体内实验均显示疫苗可诱导强烈的体液和细胞免疫。这些发现表明，基于MOF的疫苗平台可用于生产针对多种疾病的有效疫苗，这将有助于MOF在生物医学领域的应用。

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  • 来源
    《Advanced Functional Materials》 |2016年第35期|6454-6461|共8页
  • 作者

    Zhang Yan; Wang Faming; Ju Enguo; Liu Zhen; Chen Zhaowei; Ren Jinsong; Qu Xiaogang;

  • 作者单位

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China|Univ Chinese Acad Sci, Beijing 100039, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China;

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