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首页> 外文期刊>Advanced Functional Materials >Elevating Biomedical Performance of ZnO/SiO2@Amorphous Calcium Phosphate - Bioinspiration Making Possible the Impossible
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Elevating Biomedical Performance of ZnO/SiO2@Amorphous Calcium Phosphate - Bioinspiration Making Possible the Impossible

机译：提升ZnO / SiO2 @无定形磷酸钙的生物医学性能-生物启发使不可能成为可能

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摘要

Here a biomimetic approach is presented to fabricate nanodragon fruits featured by a multitude of tiny quantum dot ZnO seeds embedded in mesosilica (SiO2) flesh then enclosed in amorphous calcium phosphate (ACP) shell. The nanodragon fruits give rise to a new class of hybrid ZnO/SiO2@ACP nanocomplex with multimoidal capability: cellular delivering, intracellular targeting, and subcellular imaging. With this particular design, the unusual fluorescent stability of ZnO quantum dots (QDs) in aqueous solution, the specific color selection of the functional ZnO QD seeds, and the stability of transient ACP over a long period of time are made possible. In addition, the nanodragon fruits, capable of targeting mitochondria, have elevated biocompatibility, thus can be of enormous potential applications in treating mitochondrial diseases including inflammation, neurodegeneration, obesity, diabetes, cardiovascular diseases, and cancer. As numerous human disorders are often associated with cellular dysfunctions, this biocompatible carrying platform, capable of delivering, targeting, and imaging subcellular organelles, is therefore highly desirable for efficacious therapeutic and diagnostic treatment.
机译：在这里，提出了一种仿生方法来制造纳米龙果实，其特征是将许多微小的量子点ZnO种子嵌入中硅（SiO2）肉中，然后将其包裹在无定形磷酸钙（ACP）壳中。纳米龙的果实产生了具有多分子能力的新型一类杂化的ZnO / SiO2 @ ACP纳米复合物：细胞递送，细胞内靶向和亚细胞成像。通过这种特殊设计，可以使ZnO量子点（QD）在水溶液中具有异常的荧光稳定性，功能性ZnO QD种子的特定颜色选择以及长时间内瞬态ACP的稳定性。另外，能够靶向线粒体的纳米龙果实具有提高的生物相容性，因此在治疗线粒体疾病包括炎症，神经退行性疾病，肥胖症，糖尿病，心血管疾病和癌症方面具有巨大的潜在应用。由于许多人类疾病通常与细胞功能障碍有关，因此，对于有效的治疗和诊断治疗，这种能够传递，靶向和成像亚细胞细胞器的生物相容性携带平台是非常需要的。

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  • 来源
    《Advanced Functional Materials》 |2016年第38期|6921-6929|共9页
  • 作者

    Duc-Viet Nguyen; Jiang Shengwei; He Chengyong; Lin Zhongning; Lin Naibo; Anh-Tuan Nguyen; Kang Lifeng; Han Ming-Yong; Liu Xiang-Yang;

  • 作者单位

    Natl Univ Singapore, Ctr Life Sci, NUS Grad Sch Integrat Sci & Engn, 05-01,28 Med Dr, Singapore 117456, Singapore|Natl Univ Singapore, Dept Phys, Block S12,2 Sci Dr 3, Singapore 117551, Singapore;

    Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China;

    Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China;

    Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China;

    Xiamen Univ, Res Inst Soft Matter & Biomimet, Xiamen 361102, Peoples R China|Xiamen Univ, Fujian Prov Key Lab Soft Funct Mat Res, Xiamen 361102, Peoples R China|Xiamen Univ, Fujian Prov Key Lab Fire Retardant Mat, Xiamen 361102, Peoples R China;

    Natl Univ Singapore, Ctr Life Sci, NUS Grad Sch Integrat Sci & Engn, 05-01,28 Med Dr, Singapore 117456, Singapore|Natl Univ Singapore, Dept Phys, Block S12,2 Sci Dr 3, Singapore 117551, Singapore;

    Natl Univ Singapore, Dept Pharm, 18 Sci Dr 4, Singapore 117543, Singapore;

    Inst Mat Res & Engn, 2 Fusionopolis Way, Singapore 138634, Singapore;

    Natl Univ Singapore, Ctr Life Sci, NUS Grad Sch Integrat Sci & Engn, 05-01,28 Med Dr, Singapore 117456, Singapore|Natl Univ Singapore, Dept Phys, Block S12,2 Sci Dr 3, Singapore 117551, Singapore|Xiamen Univ, Res Inst Soft Matter & Biomimet, Xiamen 361102, Peoples R China|Xiamen Univ, Fujian Prov Key Lab Soft Funct Mat Res, Xiamen 361102, Peoples R China|Xiamen Univ, Fujian Prov Key Lab Fire Retardant Mat, Xiamen 361102, Peoples R China;

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