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首页> 外文期刊>Advanced Functional Materials >An O-2 Self-Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy
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An O-2 Self-Sufficient Biomimetic Nanoplatform for Highly Specific and Efficient Photodynamic Therapy

机译：O-2自给自足的仿生纳米平台用于高度特异性和高效的光动力疗法。

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摘要

Conventional oxygen-dependent photodynamic therapy (PDT) has faced severe challenges because of the non-specificity of most available photosensitizers (PSs) and the hypoxic nature of tumor tissues. Here, an O-2 selfsufficient cell-like biomimetic nanoplatform (CAT-PS-ZIF@Mem) consisting of the cancer cell membrane (Mem) and a cytoskeleton-like porous zeolitic imidazolate framework (ZIF-8) with the embedded catalase (CAT) protein molecules and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4, defined as PS) is developed. Because of the immunological response and homologous targeting abilities of the cancer cell membrane, CAT-PS-ZIF@ Mem is selectively accumulated at the tumor site and taken up effectively by tumor cells after intravenous injection. After the intracellular H2O2 penetration into the framework, it is catalyzed by CAT to produce O-2 at the hypoxic tumor site, facilitating the generation of toxic O-1(2) for highly effective PDT in vivo under near-infrared irradiation. By integrating the immune escape, cell homologous recognition, and O-2 self-sufficiency, this cell-like biomimetic nanoplatform demonstrates highly specific and efficient PDT against hypoxic tumor cells with much reduced side-effect on normal tissues.
机译：由于大多数可用的光敏剂（PSs）的非特异性以及肿瘤组织的缺氧性，常规的氧依赖性光动力疗法（PDT）面临着严峻的挑战。在这里，O-2自足的类似细胞的仿生纳米平台（CAT-PS-ZIF @ Mem）由癌细胞膜（Mem）和带有嵌入式过氧化氢酶（CAT）的细胞骨架状多孔沸石咪唑盐骨架（ZIF-8）组成）蛋白质分子和Al（III）酞菁氯化四磺酸（AlPcS4，定义为PS）。由于癌细胞膜的免疫应答和同源靶向能力，CAT-PS-ZIF @ Mem选择性地聚集在肿瘤部位，并在静脉注射后被肿瘤细胞有效吸收。细胞内H2O2渗透入框架后，它被CAT催化在缺氧肿瘤部位产生O-2，从而促进了在近红外辐射下体内高效PDT的毒性O-1（2）的产生。通过整合免疫逃逸，细胞同源识别和O-2自给自足，这种细胞样仿生纳米平台表现出针对缺氧肿瘤细胞的高度特异性和有效的PDT，对正常组织的副作用大大降低。

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  • 来源
    《Advanced Functional Materials》 |2016年第43期|7847-7860|共14页
  • 作者

    Cheng Hong; Zhu Jing-Yi; Li Shi-Ying; Zeng Jin-Yue; Lei Qi; Chen Ke-Wei; Zhang Chi; Zhang Xian-Zheng;

  • 作者单位

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

    Wuhan Univ, Inst Adv Studies, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China|Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China;

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