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首页> 外文期刊>Advanced Functional Materials >One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-Guided Trimodal Therapy
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One-Pot Synthesis of Dual Stimulus-Responsive Degradable Hollow Hybrid Nanoparticles for Image-Guided Trimodal Therapy

机译：一锅合成双刺激响应可降解空心杂化纳米粒子的图像指导三峰疗法。

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摘要

Exploiting exogenous and endogenous stimulus-responsive degradable nanoparticles as drug carriers can improve drug delivery systems (DDSs). The use of hollow nanoparticles may facilitate degradation, and combination of DDS with photodynamic therapy (PDT) and photothermal therapy (PTT) may enhance the anticancer effects of treatments. Here, a one-pot synthetic method is presented for an anticancer drug (doxorubicin [DOX]) and photosensitizer-containing hollow hybrid nanoparticles (HNPs) with a disulfide and siloxane framework formed in response to exogenous (light) and endogenous (intracellular glutathione [GSH]) stimuli. The hollow HNPs emit fluorescence within the near-infrared window and allow for the detection of tumors in vivo by fluorescence imaging. Furthermore, the disulfides within the HNP framework are cleaved by intracellular GSH, deforming the HNPs. Light irradiation facilitates penetration of GSH into the HNP framework and leads to the collapse of the HNPs. As a result, DOX is released from the hollow HNPs. Additionally, the hollow HNPs generate singlet oxygen (O-1(2)) and heat in response to light; thus, fluorescence imaging of tumors combined with trimodal therapy consisting of DDS, PDT, and PTT is feasible, resulting in superior therapeutic efficacy. Thus, this method may have several applications in imaging and therapeutics in the future.
机译：利用外源性和内源性刺激响应性可降解纳米粒子作为药物载体可以改善药物递送系统（DDS）。中空纳米粒子的使用可促进降解，DDS与光动力疗法（PDT）和光热疗法（PTT）的组合可增强治疗的抗癌作用。在这里，提出了一种一锅法合成方法，用于抗癌药（阿霉素[DOX]）和含光敏剂的空心杂化纳米颗粒（HNP），该杂化纳米颗粒具有对二价硫和硅氧烷骨架的形成，以应对外源性（轻度）和内源性（细胞内谷胱甘肽[ GSH]）刺激。空心HNP在近红外窗口内发出荧光，并允许通过荧光成像在体内检测肿瘤。此外，HNP框架内的二硫键被细胞内GSH裂解，使HNP变形。光照射促进GSH渗透到HNP框架中，并导致HNP崩溃。结果，DOX从空心HNP中释放出来。此外，中空的HNP会根据光产生单线态氧（O-1（2））和热量。因此，结合由DDS，PDT和PTT组成的三峰疗法，对肿瘤进行荧光成像是可行的，从而具有出色的治疗效果。因此，该方法将来可能在成像和治疗中具有多种应用。

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  • 来源
    《Advanced Functional Materials》 |2016年第47期|8613-8622|共10页
  • 作者

    Hayashi Koichiro; Maruhashi Takuma; Nakamura Michihiro; Sakamoto Wataru; Yogo Toshinobu;

  • 作者单位

    Nagoya Univ, Inst Mat & Syst Sustainabil, Div Mat Res, Chikusa Ku, Fro Cho, Nagoya, Aichi 4648603, Japan;

    Nagoya Univ, Inst Mat & Syst Sustainabil, Div Mat Res, Chikusa Ku, Fro Cho, Nagoya, Aichi 4648603, Japan;

    Yamaguchi Univ, Grad Sch Med, Dept Organ Anat, 1-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan;

    Nagoya Univ, Inst Mat & Syst Sustainabil, Div Mat Res, Chikusa Ku, Fro Cho, Nagoya, Aichi 4648603, Japan;

    Nagoya Univ, Inst Mat & Syst Sustainabil, Div Mat Res, Chikusa Ku, Fro Cho, Nagoya, Aichi 4648603, Japan;

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