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Flexible, Graphene-Coated Biocomposite for Highly Sensitive, Real-Time Molecular Detection

机译：灵活的石墨烯涂层生物复合材料，用于高度灵敏的实时分子检测

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摘要

Wearable biosensors hold significant potential for healthcare and environmental applications, and the development of flexible and biocompatible sensing platforms for high accuracy detection of physiological biomarkers remains an elusive goal. Herein, an ultrasensitive, flexible sensor is described that is based on a 3D hierarchical biocomposite comprised of hollow, natural pollen microcapsules that are coated with a conductive graphene layer. Modular assembly of the graphene-coated microcapsules onto an ultrathin polyethylene terephthalate layer enables a highly flexible sensor configuration with tunable selectivity afforded by subsequent covalent immobilization of antibodies against target antigens. In a proof-of-concept example, the biosensor demonstrates ultrahigh sensitivity detection of prostate specific antigen (PSA) down to 1.7 x 10(-15) M with real-time feedback and superior performance over conventional 2D graphene-coated sensors. Importantly, the device performance is consistently high across various bending conditions. Taken together, the results demonstrated in this work highlight the merits of employing lightweight biocomposites as modular building blocks for the design of flexible biosensors with highly responsive and sensitive molecular detection capabilities.
机译：可穿戴式生物传感器在医疗保健和环境应用领域具有巨大潜力，而开发灵活且生物相容的传感平台以高精度检测生理生物标志物仍然是一个遥不可及的目标。本文中，描述了一种超灵敏的柔性传感器，该传感器基于3D分层生物复合材料，该复合材料由中空的天然花粉微胶囊组成，并包覆有导电石墨烯层。将石墨烯涂层的微胶囊模块化组装到超薄聚对苯二甲酸乙二酯层上，可以实现高度灵活的传感器配置，并通过随后针对目标抗原的抗体共价固定化提供可调的选择性。在概念验证的示例中，该生物传感器演示了低至1.7 x 10（-15）M的前列腺特异性抗原（PSA）的超高灵敏度检测，具有实时反馈，并且性能优于传统的2D石墨烯涂层传感器。重要的是，在各种弯曲条件下，设备性能始终很高。综上所述，这项工作中展示的结果突出了采用轻质生物复合材料作为模块化构建模块的优点，这些模块可用于设计具有高响应能力和灵敏分子检测功能的柔性生物传感器。

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  • 来源
    《Advanced Functional Materials》 |2016年第47期|8623-8630|共8页
  • 作者

    Wang Lili; Jackman Joshua A.; Ng Wei Beng; Cho Nam-Joon;

  • 作者单位

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore|Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore;

    Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore|Nanyang Technol Univ, Ctr Biomimet Sensor Sci, 50 Nanyang Dr, Singapore 637553, Singapore|Nanyang Technol Univ, Sch Chem & Biomed Engn, 62 Nanyang Dr, Singapore 637459, Singapore;

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