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PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

机译：结合Ga螯合物的聚乙二醇化聚吡咯纳米颗粒用于双模态MRI /光声成像引导的癌症光热疗法

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摘要

Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoa-coustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. The obtained PEGylated polypyrrole nanoparticles conjugating gadolinium chelates (Gd-PEG-PPy NPs), sized around around 70 nm, exhibited a high T_1 relaxivity coefficient of 10.61 L mm~(-1) s~(-1), more than twice as high as that of the relating free Gd~(3+) complex (4.2 L mm~(-1) s~(-1)). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T_1-weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the efficient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photo-acoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective "personalized medicine," showing great potential for cancer diagnosis and therapy.
机译：吡咯和吡咯-1-丙酸的混合物通过简便的一步式水分散聚合反应成功制备了结合py螯合物的聚吡咯纳米颗粒，用于双模式磁共振成像（MRI）和光声成像引导的癌症光热疗法。 ，然后使用聚乙二醇作为接头共价结合of螯合物。所得的与con螯合物（Gd-PEG-PPy NPs）共轭的PEG化聚吡咯纳米粒子的尺寸约为70 nm，其高T_1弛豫系数为10.61 L mm〜（-1）s〜（-1），是其两倍以上。与相关的游离Gd〜（3+）络合物（4.2 L mm〜（-1）s〜（-1））相同。静脉注射Gd-PEG-PPy NP后24 h，与注射前相比，肿瘤部位的T_1加权MRI强度和光声信号均明显增强，表明Gd-PEG-PPy NPs的有效积累。 PEG层在颗粒表面上。另外，在用Gd-PEG-PPy NPs与近红外激光照射相结合后，可以有效抑制肿瘤的生长。 Gd-PEG-PPy NPs的被动靶向和高MRI /光声对比能力非常有利于精确的癌症诊断和定位肿瘤部位，以指导外部激光照射对肿瘤进行光热消融而不损害周围的健康组织。因此，Gd-PEG-PPy NP可能有助于更好地监测治疗过程，并有助于开发更有效的“个性化药物”，显示出在癌症诊断和治疗方面的巨大潜力。

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  • 来源
    《Advanced Functional Materials》 |2015年第9期|1451-1462|共12页
  • 作者

    Xiaolong Liang; Yanyan Li; Xiaoda Li; Lijia Jing; Zijian Deng; Xiuli Yue; Changhui Li; Zhifei Dai;

  • 作者单位

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, P.R. China;

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin 150080, P.R.China;

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin 150080, P.R.China;

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin 150080, P.R.China;

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, P.R. China;

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin 150080, P.R.China;

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, P.R. China;

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, P.R. China;

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