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TAPE: A Medical Adhesive Inspired by a Ubiquitous Compound in Plants

机译：TAPE：一种植物中无处不在的化合物启发的医用胶粘剂

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摘要

Adhesives play an important role in industrial fields such as electronics, architectures, energy plantation, and others. However, adhesives used for medical purpose are rather under-developed compared with those used in industry and consumer products. One key property required for medical adhesives is to maintain their adhesiveness in the presence of body fluid. Here, an entirely new class of medical adhesives called TAPE is reported; this is produced by intermolecular hydrogen bonding between a well-known polyphenol compound, tannic acid, and poly(ethylene glycol). The preparation method of TAPE is extremely easy, forming a few liters at once by just the simple mixing of the two compounds without any further chemical synthetic procedures. TAPE shows a 250% increase in adhesion strength compared with fibrin glue, and the adhesion is well maintained in aqueous environments. It is demonstrated that TAPE is an effective hemostatic material and a biodegradable patch for detecting gastroesophageal reflux disease in vivo. Widespread use of TAPE is anticipated in various medical and pharmaceutical applications such as muco-adhesives, drug depots, and others, because of its scalability, adhesion, and facile preparation.
机译：粘合剂在电子，建筑，能源种植园等工业领域中发挥着重要作用。但是，与工业和消费产品中使用的粘合剂相比，用于医疗目的的粘合剂还不够发达。医用粘合剂所需的一项关键性能是在体液存在下保持其粘合性。在这里，报道了一种全新的医用胶粘剂，称为TAPE。这是通过众所周知的多酚化合物，鞣酸和聚乙二醇之间的分子间氢键产生的。 TAPE的制备方法非常容易，只需将两种化合物简单混合即可一次形成几升，而无需任何其他化学合成步骤。与纤维蛋白胶相比，TAPE的粘合强度提高了250％，在水性环境中可以很好地保持粘合性。结果表明，TAPE是一种有效的止血材料，是一种可体内检测胃食管反流疾病的可生物降解的贴剂。由于其可扩展性，粘合性和制备简便性，人们期望在各种医疗和制药应用中广泛使用TAPE，例如粘膜胶粘剂，药品仓库等。

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  • 来源
    《Advanced Functional Materials》 |2015年第16期|2402-2410|共9页
  • 作者

    Kim Keumyeon; Shin Mikyung; Koh Mi-Young; Ryu Ji Hyun; Lee Moon Sue; Hong Seonki; Lee Haeshin;

  • 作者单位

    Korea Adv Inst Sci & Technol, Grad Sch Sci & Technol, Taejon 305701, South Korea|InnoTherapy Inc, Seoul 150737, South Korea;

    Korea Adv Inst Sci & Technol, Grad Sch Sci & Technol, Taejon 305701, South Korea;

    InnoTherapy Inc, Seoul 150737, South Korea;

    Korea Adv Inst Sci & Technol, Grad Sch Sci & Technol, Taejon 305701, South Korea;

    InnoTherapy Inc, Seoul 150737, South Korea;

    Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea;

    Korea Adv Inst Sci & Technol, Grad Sch Sci & Technol, Taejon 305701, South Korea|Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea;

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