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A New Single 808 nm NIR Light-Induced Imaging-Guided Multifunctional Cancer Therapy Platform

机译：新型单808 nm NIR光诱导成像引导多功能癌症治疗平台

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摘要

The NIR light-induced imaging-guided cancer therapy is a promising route in the targeting cancer therapy field. However, up to now, the existing single-modality light-induced imaging effects are not enough to meet the higher diagnosis requirement. Thus, the multifunctional cancer therapy platform with multimode light-induced imaging effects is highly desirable. In this work, captopril stabilized-Au nanoclusters Au-25(Capt)(18)-(Au-25) are assembled into the mesoporous silica shell coating outside of Nd3+-sensitized upconversion nanoparticles (UCNPs) for the first time. The newly formed Au-25 shell exhibits considerable photothermal effects, bringing about the photothermal imaging and photoacoustic imaging properties, which couple with the upconversion luminescence imaging. More importantly, the three light-induced imaging effects can be simultaneously achieved by exciting with a single NIR light (808 nm), which is also the triggering factor for the photothermal and photodynamic cancer therapy. Besides, the nanoparticles can also present the magnetic resonance and computer tomography imaging effects due to the Gd3+ and Yb3+ ions in the UCNPs. Furthermore, due to the photodynamic and the photothermal effects, the nanoparticles possess efficient in vivo tumor growth inhibition under the single irradiation of 808 nm light. The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light-induced imaging-guided cancer therapy.
机译：NIR光诱导成像指导的癌症治疗是靶向癌症治疗领域中有希望的途径。然而，到目前为止，现有的单模态光诱导成像效果还不足以满足更高的诊断要求。因此，非常需要具有多模光诱导成像效果的多功能癌症治疗平台。在这项工作中，第一次将卡托普利稳定化的Au纳米簇Au-25（Capt）（18）-（Au-25）组装到Nd3 +敏化上转换纳米颗粒（UCNPs）外部的介孔二氧化硅壳涂层中。新形成的Au-25壳具有显着的光热效应，带来了光热成像和光声成像特性，并与上转换发光成像相结合。更重要的是，可以通过用单个NIR光（808 nm）激发来同时获得这三种光诱导的成像效果，这也是光热和光动力癌症治疗的触发因素。此外，由于UCNPs中的Gd3 +和Yb3 +离子，纳米粒子还可以表现出磁共振和计算机断层扫描成像效果。此外，由于光动力和光热效应，纳米颗粒在808nm光的单次照射下具有有效的体内肿瘤生长抑制作用。具有多模式成像效果的多功能癌症治疗平台可实现真正意义上的光诱导成像指导的癌症治疗。

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  • 来源
    《Advanced Functional Materials》 |2015年第25期|3966-3976|共11页
  • 作者

    He Fei; Yang Guixin; Yang Piaoping; Yu Yuxiu; Lv Ruichan; Li Chunxia; Dai Yunlu; Gai Shili; Lin Jun;

  • 作者单位

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130021, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130021, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Au clusters; multimode imaging; photodynamic therapy; photothermal therapy; upconversion;

    机译：金团簇;多模成像;光动力疗法;光热疗法;上转换;

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