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Three Dimensional Graphene Foam/Polymer Hybrid as a High Strength Biocompatible Scaffold

机译：三维石墨烯泡沫/聚合物杂化物作为高强度生物相容性支架

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摘要

Graphene foam (GrF)/polylactic acid-poly-epsilon-caprolactone copolymer (PLC) hybrid (GrF-PLC) scaffold is synthesized in order to utilize both the desirable properties of graphene and that of foams such as excellent structural characteristics and a networked 3-D structure for cells to proliferate in. The hybrid scaffold is synthesized by a dip-coating method that enables retention of the porous 3D structure. The excellent wettability of PLC with graphene foam along with the formation of PLC bridges leads to a approximate to 3700% enhancement in strength and a approximate to 3100% increase in ductility in the GrF-PLC scaffold. Biocompatibility of both graphene foam and GrF-PLC scaffold is demonstrated by culturing of human mesenchymal stem cells (hMSCs) for 28 days, a period over which cell proliferation is robust. The hMSCs are differentiated in chondrogenic media and supported chondrogenesis in both scaffolds. The demand for aggrecan extracellular matrix protein synthesis is reduced in hybrids due to improved bearing of cell-induced loads, this may be critical for ensuring adequate cellular distribution and layering of extracellular matrix. Hence, the unique mechanical and biotolerant properties of the GrF-PLC scaffold are suited for musculoskeletal tissue engineering applications, such as the growth of de novo cartilage to replace cartilage lost due to injury or osteoarthritis.
机译：合成石墨烯泡沫（GrF）/聚乳酸-聚ε-己内酯共聚物（PLC）杂化（GrF-PLC）支架，以便利用石墨烯和泡沫的理想特性，例如出色的结构特征和网状结构3 -D结构用于细胞增殖。通过浸涂法合成杂化支架，该浸涂法能够保留多孔3D结构。 PLC与石墨烯泡沫的优异润湿性以及PLC桥的形成导致GrF-PLC支架的强度提高了约3700％，延展性提高了约3100％。石墨烯泡沫和GrF-PLC支架的生物相容性通过人类间充质干细胞（hMSCs）培养28天来证明，在这段时间内细胞增殖很强劲。 hMSCs在软骨形成介质中分化并在两种支架中支持软骨形成。由于改善了细胞诱导的负荷，杂交物中对聚集蛋白聚糖细胞外基质蛋白合成的需求减少了，这对于确保足够的细胞分布和细胞外基质的分层可能至关重要。因此，GrF-PLC支架的独特机械和生物耐受性特性适用于肌肉骨骼组织工程应用，例如从头软骨的生长来替代由于受伤或骨关节炎而丢失的软骨。

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