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首页> 外文期刊>Advanced Functional Materials >Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery
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Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery

机译：基于树突脂肽的病毒启发模拟物，可有效进行肿瘤特异性感染和全身药物递送

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摘要

Herein, multifunctional mimics of viral architectures and infections self-assembled from tailor-made dendritic lipopeptides for programmed targeted drug delivery are reported. These viral mimics not only have virus-like components and nanostructures, but also possess virus-like infections to solid tumor and tumor cells. Encouragingly, the viral mimics provide the following distinguished features for tumor-specific systemic delivery: i)stealthy surface to resist protein interactions and prolong circulation time in blood, ii) well-defined nanostructure for passive targeting to solid tumor site, iii)charge-tunable shielding for tumor extracellular pH targeting, iv) receptor-mediated targeting to enhance tumor-specific uptake, and v) supramolecular lysine-rich architectures mimicking viral subcellular targeting for efficient endosomal escape and nuclear delivery. This bioinspired design make in vivo tumor suppression by drug-loaded viral mimics against BALB/c mice bearing 4T1 tumor greatly exceed the positive control group (more than three times). More importantly, viral mimics hold great potentials to reduce side effects and decrease tumor metastasis after systemic administration.
机译：在本文中，报道了从特制的树突脂肽自组装用于程序化靶向药物递送的病毒结构和感染的多功能模拟物。这些病毒模拟物不仅具有病毒样成分和纳米结构，而且还具有对实体瘤和肿瘤细胞的病毒样感染。令人鼓舞的是，病毒模拟物为肿瘤特异性的全身递送提供了以下杰出特征：i）隐形表面可抵抗蛋白质相互作用并延长血液中的循环时间； ii）明确定义的纳米结构，可被动靶向实体瘤部位； iii）电荷-用于肿瘤细胞外pH靶向的可调屏蔽，iv）受体介导的靶向以增强肿瘤特异性摄取，v）模仿病毒亚细胞靶向的超分子赖氨酸丰富的架构，可有效地进行内体逃逸和核传递。这种受生物启发的设计使载有病毒的模拟药物对带有4T1肿瘤的BALB / c小鼠的体内肿瘤抑制作用大大超过了阳性对照组（超过三倍）。更重要的是，在全身性给药后，病毒模拟物具有减少副作用和减少肿瘤转移的巨大潜力。

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