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首页> 外文期刊>Advanced Functional Materials >Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis
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Remarkable NIR Enhancement of Multifunctional Nanoprobes for In Vivo Trimodal Bioimaging and Upconversion Optical/T-2-Weighted MRI-Guided Small Tumor Diagnosis

机译：多功能纳米探针在体内三峰生物成像和上转换光学/ T-2-加权MRI指导的小肿瘤诊断中的显着NIR增强

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摘要

Effective nanoprobes and contrast agents are urgently sought for early-stage cancer diagnosis. Upconversion nanoparticles (UCNPs) are considerable alternatives for bioimaging, cancer diagnosis, and therapy. Yb3+/ Tm3+ co-doping brings both emission and excitation wavelengths into the near-infrared (NIR) region, which is known as "optical transmission window" and ideally suitable for bioimaging. Here, NIR emission intensity is remarkably enhanced by 113 times with the increase of Yb3+ concentration from 20% to 98% in polyethylene glycol ( PEG) modified NaYF4:Yb3+/ Tm3+ UCNPs. PEG-UCNPs-5 (98% Yb3+) can act as excellent nanoprobes and contrast agents for trimodal upconversion (UC) optical/CT/T-2-weighted magnetic resonance imaging (MRI). In addition, the enhanced detection of lung in vivo long-lasting tracking, as well as possible clearance mechanism and excretion routes of PEG-UCNPs-5 have been demonstrated. More significantly, a small tumor down to 4 mm is detected in vivo via intravenous injection of these nanoprobes under both UC optical and T-2-weighted MRI modalities. PEG-UCNPs-5 can emerge as bioprobes for multi-modal bioimaging, disease diagnosis, and therapy, especially the early-stage tumor diagnosis.
机译：迫切需要有效的纳米探针和造影剂来进行早期癌症诊断。上转换纳米颗粒（UCNP）是生物成像，癌症诊断和治疗的重要替代方法。 Yb3 + / Tm3 +共掺杂可将发射和激发波长带入近红外（NIR）区域，该区域被称为“光学透射窗”，非常适合生物成像。在此，随着聚乙二醇（PEG）修饰的NaYF4：Yb3 + / Tm3 + UCNPs中Yb3 +浓度从20％增加到98％，NIR发射强度显着提高了113倍。 PEG-UCNPs-5（98％Yb3 +）可以作为出色的纳米探针和造影剂，用于三峰上转换（UC）光学/ CT / T-2-加权磁共振成像（MRI）。另外，已经证明了增强的肺体内持久追踪的检测以及PEG-UCNPs-5的可能的清除机制和排泄途径。更重要的是，在UC光学和T-2加权MRI模式下，通过静脉内注射这些纳米探针，可以在体内检测到小至4 mm的小肿瘤。 PEG-UCNPs-5可以作为生物探针用于多模式生物成像，疾病诊断和治疗，尤其是早期肿瘤诊断。

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  • 来源
    《Advanced Functional Materials》 |2015年第46期|7119-7129|共11页
  • 作者

    Yi Zhigao; Li Xiaolong; Xue Zhenluan; Liang Xiao; Lu Wei; Peng Hao; Liu Hongrong; Zeng Songjun; Hao Jianhua;

  • 作者单位

    Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China|Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China|Xiangtan Univ, Sch Mat Sci & Engn, Key Lab Low Dimens Mat & Applicat Technol, Minist Educ, Xiangtan 411105, Peoples R China;

    Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China|Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China|Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China;

    Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China;

    Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China|Hong Kong Polytech Univ, Mat Res Ctr, Hong Kong, Hong Kong, Peoples R China;

    Hunan Normal Univ, Sch Life Sci, Res Ctr Heart Dev, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China|Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China;

    Hunan Normal Univ, Coll Phys & Informat Sci, Changsha 410081, Hunan, Peoples R China|Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Changsha 410081, Hunan, Peoples R China;

    Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China|Hong Kong Polytech Univ, Mat Res Ctr, Hong Kong, Hong Kong, Peoples R China;

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