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首页> 外文期刊>Advanced Functional Materials >Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer
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Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

机译：聚多巴胺作为一种生物相容性多功能纳米载体，可用于放射性同位素联合疗法和癌症化学疗法。

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摘要

Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as Tc-99m and I-131, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with Tc-99m (Tc-99m-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with I-131 and DOX (I-131-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment.
机译：近年来，用于药物输送和癌症治疗学的可生物降解纳米材料的开发引起了极大的关注。在这项工作中，开发了一种生物相容性聚合物聚多巴胺（PDA），作为一种有前途的载体，可同时装载放射性核素和抗癌药，以在一个系统中实现核成像引导的放射性同位素联合疗法（RIT）和癌症的化学疗法。发现用聚（乙二醇）（PEG）修饰后的PDA纳米颗粒可以成功加载多种不同的放射性核素，例如Tc-99m和I-131，以及抗癌药阿霉素（DOX）。虽然用Tc-99m标记PDA-PEG（Tc-99m-PDA-PEG）可以进行体内单光子发射计算机断层扫描成像，但与I-131和DOX（I-131-PDA-PEG / DOX）共载的纳米颗粒可以将其用于RIT和化学疗法的联合，其以显着协同的方式提供有效的癌症治疗功效，而对被治疗的动物没有明显的毒性。因此，这项研究提出了一种有趣的生物相容性纳米载体，它可以将RIT和化学疗法结合起来，这两种广泛应用的癌症治疗策略，有望在癌症治疗中用于未来的临床翻译。

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  • 来源
    《Advanced Functional Materials》 |2015年第47期|7327-7336|共10页
  • 作者

    Zhong Xiaoyan; Yang Kai; Dong Zhiliang; Yi Xuan; Wang Yong; Ge Cuicui; Zhao Yuliang; Liu Zhuang;

  • 作者单位

    Soochow Univ, Sch Radiat Med & Protect, Jiangsu Higher Educ Inst, Coll Med, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst,Coll Med, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Jiangsu Higher Educ Inst, Coll Med, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst,Coll Med, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Jiangsu Higher Educ Inst, Coll Med, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst,Coll Med, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Jiangsu Higher Educ Inst, Coll Med, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst,Coll Med, Suzhou 215123, Jiangsu, Peoples R China;

    Soochow Univ, Sch Radiat Med & Protect, Jiangsu Higher Educ Inst, Coll Med, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst,Coll Med, Suzhou 215123, Jiangsu, Peoples R China;

    Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China;

    Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China|Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    drug delivery; polydopamine; radioisotope therapy; radiolabeling; SPECT imaging;

    机译：药物输送;聚多巴胺;放射性同位素疗法;放射标记;SPECT成像;

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