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A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy

机译：顺序照射激活的高性能细胞凋亡癌症治疗的多协同平台。

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摘要

Artificial hyperthermia is an emerging technique to induce apoptotic cancer cell death. However, achieving effective hyperthermic apoptosis is often difficult, as cells typically acquire resistance to thermal stress. With the aid of sequential irradiation, highly integrated nanoassemblies based on reduced graphene oxide-ZnO nanoparticles-hyaluronic acid (rCo-ZnO-HA) can serve as a multi-synergistic platform for targeted high-performance apoptotic cancer therapy. The surface engineering of ZnO/graphene hybrid with multifunctional HA biomacromolecules simultaneously confers the system colloidal stability, biocompatibility, and a cancer cell targeting ability. After receptor-mediated endocytosis, enzyme-mediated fluorescence activation helps track cellular uptake and provides truly molecular imaging. Furthermore, the reactive oxygen species (ROS) generated by ZnO/rGo under light illumination can effectively sensitize cancer cells to the subsequent NIR laser-induced apoptotic hyperthermia. In particular, photo modulation of cellular ROS to sensitize cells provides a novel approach to increase the efficacy of hyperthermic apoptosis. These findings suggest that a powerful apoptotic therapeutic platform could be achieved based on the multi-synergistic platform.
机译：人工体温过高是诱导凋亡性癌细胞死亡的新兴技术。然而，由于细胞通常获得对热应激的抗性，因此通常难以实现有效的高温凋亡。借助顺序照射，基于还原型氧化石墨烯-ZnO纳米颗粒-透明质酸（rCo-ZnO-HA）的高度集成的纳米组件可以用作靶向性高性能凋亡治疗的多协同平台。具有多功能HA生物大分子的ZnO /石墨烯杂化体的表面工程设计同时赋予系统胶体稳定性，生物相容性和癌细胞靶向能力。受体介导的内吞作用后，酶介导的荧光激活有助于追踪细胞摄取并提供真正的分子成像。此外，ZnO / rGo在光照下产生的活性氧（ROS）可以有效地使癌细胞对随后的NIR激光诱导的凋亡热疗敏感。特别地，细胞ROS对光敏细胞的光调制提供了一种增加高温细胞凋亡功效的新颖方法。这些发现表明，基于多协同平台可以实现强大的凋亡治疗平台。

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  • 来源
    《Advanced Functional Materials》 |2014年第4期|522-529|共8页
  • 作者

    Zhaowei Chen; Zhenhua Li; Jiasi Wang; Enguo Ju; Li Zhou; Jinsong Ren; Xiaogang Qu;

  • 作者单位

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

    State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,Graduate School of the Chinese Academy of Sciences Beijing, 100039, China;

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