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首页> 外文期刊>Advanced Functional Materials >Gold-Coated Fe_3O_4 Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging, and Therapy
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Gold-Coated Fe_3O_4 Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging, and Therapy

机译：具有癌细胞靶向，成像和治疗五种独特功能的镀金Fe_3O_4 Nanoroses

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摘要

The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis and therapy will provide the multimodality needed for accurate diagnosis and targeted therapy. Here, gold-coated iron oxide (Fe_3O_4@Au) nanoroses with five distinct functions are demonstrated, integrating aptamer-based targeting, magnetic resonance imaging (MRI), optical imaging, photothermal therapy, and chemotherapy into one single probe. The inner Fe_3O_4 core functions as an MRI agent, while the photothermal effect is achieved through near-infrared absorption by the gold shell, causing a rapid rise in temperature and also resulting in a facilitated release of the anticancer drug doxorubicin carried by the nanoroses. Where the doxorubicin is released, it is monitored by its fluorescence. Aptamers immobilized on the surfaces of the nanoroses enable efficient and selective drug delivery, imaging, and photothermal effect with high specificity. The five-function-embedded nanoroses show great advantages in multimodality.
机译：在单个纳米平台内结合诊断和治疗功能的纳米材料的开发对于分子医学极为重要。同时进行诊断和治疗的分子成像将提供准确诊断和靶向治疗所需的多模态。在这里，展示了具有五种不同功能的镀金氧化铁（Fe_3O_4 @ Au）纳米玫瑰，它们将基于适体的靶向，磁共振成像（MRI），光学成像，光热疗法和化学疗法整合到一个探针中。内部Fe_3O_4核芯起MRI剂的作用，而光热效应是通过金壳的近红外吸收来实现的，从而引起温度的快速升高，并且还促进了纳米玫瑰所携带的抗癌药阿霉素的释放。阿霉素释放的地方，通过其荧光进行监测。固定在纳米玫瑰表面的适体可实现高效且选择性的药物输送，成像以及具有高特异性的光热效应。嵌入五功能的纳米玫瑰在多模态方面显示出巨大的优势。

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  • 来源
    《Advanced Functional Materials》 |2014年第12期|1772-1780|共9页
  • 作者

    Chunmei Li; Tao Chen; Ismail Ocsoy; Guizhi Zhu; Emir Yasun; Mingxu You; Cuichen Wu; Jing Zheng; Erqun Song; Cheng Zhi Huang; Weihong Tan;

  • 作者单位

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA,Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis College of Chemistry and Chemical Engineering College of Pharmaceutical Science Southwest University Chongqing, 400715, China;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA,Molecular Sciences and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering and College of Biology Collaborative Innovation Center for Chemistry and Molecular Medicine Hunan University Changsha, 410082, China;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA,Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis College of Chemistry and Chemical Engineering College of Pharmaceutical Science Southwest University Chongqing, 400715, China;

    Ministry of Education Key Laboratory on Luminescence and Real-Time Analysis College of Chemistry and Chemical Engineering College of Pharmaceutical Science Southwest University Chongqing, 400715, China;

    Center for Research at Bio/Nano Interface Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville, FL, 32611-7200, USA,Molecular Sciences and Biomedicine Laboratory State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering and College of Biology Collaborative Innovation Center for Chemistry and Molecular Medicine Hunan University Changsha, 410082, China;

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