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首页> 外文期刊>Advanced Functional Materials >Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer-Targeted Drug Delivery In Vivo
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Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer-Targeted Drug Delivery In Vivo

机译：具有生物相容性，均一性和可再分散性的介孔二氧化硅纳米颗粒，用于体内靶向癌症的药物输送

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Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods to optimize physicochemical characteristics and surface composition of the drug nanocarriers need to be developed in order to tackle major challenges for smooth translation of suitable nanocarriers to clinical applications. Here, rational development and utilization of multifunctional mesoporous silica nanoparticles (MSNPs) for targeting MDA-MB-231 xenograft model breast cancer in vivo are reported. Uniform and redispersible poly(ethylene glycol)-incorporated MSNPs with three different sizes (48, 72,100 nm) are synthesized. They are then functionalized with amino-β-cyclodextrin bridged by cieavable disulfide bonds, where amino-β-cyclodextrin blocks drugs inside the mesopores. The incorporation of active folate targeting ligand onto 48 nm of multifunctional MSNPs (PEG-MSNPs48-CD-PEG-FA) leads to improved and selective uptake of the nanoparticles into tumor. Targeted drug delivery capability of PEG-MSNPs48-CD-PEG-FA is demonstrated by significant inhibition of the tumor growth in mice treated with doxorubicin-loaded nanoparticles, where doxorubicin is released triggered by intracellular acidic pH and glutathione. Doxorubicin-loaded PEG-MSNPs48-CD-PEG-FA exhibits better in vivo therapeutic efficacy as compared with free doxorubicin and non-targeted nanoparticles. Current study presents successful utilization of multifunctional MSNP-based drug nanocarriers for targeted cancer therapy in vivo.
机译：工程化的多功能纳米载体用于靶向药物递送显示出有望改变癌症化学疗法的潜力。为了解决将合适的纳米载体顺利转化为临床应用的主要挑战，需要开发优化药物纳米载体的理化特性和表面组成的简单方法。在此，报道了在体内靶向MDA-MB-231异种移植模型乳腺癌的多功能中孔二氧化硅纳米粒子（MSNP）的合理开发和利用。合成了具有三种不同尺寸（48、72,100 nm）的均匀且可再分散的聚（乙二醇）结合的MSNP。然后将它们用通过可切割的二硫键桥接的氨基-β-环糊精进行功能化，其中氨基-β-环糊精可阻断中孔内的药物。将活性叶酸靶向配体掺入到48 nm的多功能MSNP（PEG-MSNPs48-CD-PEG-FA）上可以改善纳米颗粒对肿瘤的选择性吸收。 PEG-MSNPs48-CD-PEG-FA的靶向药物递送能力通过用载有阿霉素的纳米颗粒处理的小鼠中的肿瘤生长得到显着抑制而证实，其中阿霉素由细胞内酸性pH和谷胱甘肽触发而释放。与游离阿霉素和非靶向纳米颗粒相比，阿霉素负载的PEG-MSNPs48-CD-PEG-FA表现出更好的体内治疗效果。当前的研究显示了基于多功能MSNP的药物纳米载体在体内靶向癌症治疗中的成功利用。

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  • 来源
    《Advanced Functional Materials》 |2014年第17期|2450-2461|共12页
  • 作者

    Quan Zhang; Xiaoling Wang; Pei-Zhou Li; Kim True Nguyen; Xiao-Jun Wang; Zhong Luo; Huacheng Zhang; Nguan Soon Tan; Yanli Zhao;

  • 作者单位

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371,Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education School of Biotechnology Jiangnan University Lihu Avenue 1800, Wuxi, China, 214122;

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371;

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371;

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371;

    School of Biological Sciences Nanyang Technological University 60 Nanyang Drive, Singapore, 637551;

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371;

    Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link, Singapore, 637371;

    School of Biological Sciences Nanyang Technological University 60 Nanyang Drive, Singapore, 637551,;

    School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue, Singapore, 639798;

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