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首页> 外文期刊>Advanced Functional Materials >Electro-Drawn Drug-Loaded Biodegradable Polymer Microneedles as a Viable Route to Hypodermic Injection
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Electro-Drawn Drug-Loaded Biodegradable Polymer Microneedles as a Viable Route to Hypodermic Injection

机译：电吸药物负载的生物可降解聚合物微针作为皮下注射的可行途径

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摘要

Hypodermic needle injection is still the most common method of drug delivery despite its numerous limitations and drawbacks, such as pain, one-shot administration, and risk of infection. Seeking a viable, safe, and pain-free alternative to the over 16 billion injections per year has therefore become a top priority for our modern technological society. Here, a system that uses a pyroelectric cartridge in lieu of the syringe piston as a potential solution is discussed. Upon stimulation, the cartridge electro-draws, at room temperature, an array of drug-encapsulated, biodegradable polymer microneedles, able to deliver into hypodermic tissue both hydrophobic and hydrophilic bio-active agents, according to a predefined chrono-programme. This mould-free and contact-free method permits the fabrication of biodegradable polymer microneedles into a ready-to-use configuration. In fact, they are formed on a flexible substrate/holder by drawing them directly from drop reservoirs, using a controlled electro-hydrodynamic force. Tests of insertion are performed and discussed in order to demonstrate the possibility to prepare microneedles with suitable geometric and mechanical properties using this method.
机译：尽管皮下注射针头有许多局限性和缺点，例如疼痛，一次性注射和感染风险，但皮下注射仍是最常用的药物递送方法。因此，寻求一种每年超过160亿次注射的可行，安全且无痛苦的替代方法已成为我们现代技术社会的头等大事。这里，讨论了一种使用热电盒代替注射器活塞作为潜在解决方案的系统。受到刺激后，根据预定的程序，药筒在室温下将一系列药物包裹的，可生物降解的聚合物微针电吸，能够将皮下组织中的疏水性和亲水性生物活性剂同时传递给皮下组织。这种无霉菌和无接触的方法允许将可生物降解的聚合物微针制造成随时可用的配置。实际上，它们是通过使用受控的电动流体动力直接从液滴容器中抽出而在柔性基板/支架上形成的。进行插入测试并进行讨论，以证明使用这种方法制备具有合适几何和机械性能的微针的可能性。

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  • 来源
    《Advanced Functional Materials》 |2014年第23期|3515-3523|共9页
  • 作者

    Raffaele Vecchione; Sara Coppola; Eliana Esposito; Costantino Casale; Veronica Vespini; Simonetta Grilli; Pietro Ferraro; Paolo Antonio Netti;

  • 作者单位

    Istituto Nazionale di Ottica, Unita di Napoli Via Campi Flegrei 34, 80078, Pozzuoli Napoli, Italy,Center for Advanced Biomaterials for Health Care - IIT@CRIB Istituto Italiano di Tecnologia - Largo Barsanti e Matteucci 53 80125 Napoli, Italy;

    Istituto Nazionale di Ottica, Unita di Napoli Via Campi Flegrei 34, 80078, Pozzuoli Napoli, Italy,Centro di Ricerca Interdipartimentale sui Biomateriali - CRIB Universita di Napoli Federico Ⅱ Piazzale Tecchio, 80 80125 Napoli, Italy;

    Center for Advanced Biomaterials for Health Care - IIT@CRIB Istituto Italiano di Tecnologia - Largo Barsanti e Matteucci 53 80125 Napoli, Italy,Centro di Ricerca Interdipartimentale sui Biomateriali - CRIB Universita di Napoli Federico Ⅱ Piazzale Tecchio, 80 80125 Napoli, Italy;

    Centro di Ricerca Interdipartimentale sui Biomateriali - CRIB Universita di Napoli Federico Ⅱ Piazzale Tecchio, 80 80125 Napoli, Italy;

    Istituto Nazionale di Ottica, Unita di Napoli Via Campi Flegrei 34, 80078, Pozzuoli Napoli, Italy;

    Istituto Nazionale di Ottica, Unita di Napoli Via Campi Flegrei 34, 80078, Pozzuoli Napoli, Italy;

    Istituto Nazionale di Ottica, Unita di Napoli Via Campi Flegrei 34, 80078, Pozzuoli Napoli, Italy;

    Center for Advanced Biomaterials for Health Care - IIT@CRIB Istituto Italiano di Tecnologia - Largo Barsanti e Matteucci 53 80125 Napoli, Italy,Centro di Ricerca Interdipartimentale sui Biomateriali - CRIB Universita di Napoli Federico Ⅱ Piazzale Tecchio, 80 80125 Napoli, Italy;

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