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首页> 外文期刊>Advanced Functional Materials >Nanoporous Hydrogen Bonded Polymeric Microparticles: Facile and Economic Production of Cross Presentation Promoting Vaccine Carriers
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Nanoporous Hydrogen Bonded Polymeric Microparticles: Facile and Economic Production of Cross Presentation Promoting Vaccine Carriers

机译：纳米孔氢键键合的聚合物微粒：交叉展示促进疫苗载体的便捷和经济生产。

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摘要

Nanoporous microparticles are produced in a single step based on hydrogen bonding between a neutral polymer and tannic acid. These particles are stable in physiological medium, are non-toxic to in vitro cultured cells, and can efficiently encapsulate proteins. In vitro and in vivo experiments show that these porous hydrogen bonded microparticles are able to induce antigen-specific cellular and humoral immune responses against encapsulated vaccine antigens. Considering the easy and low cost manufacturing of this dry powder formulation from approved readily available components, it is anticipated that this technology holds great promise for the formulation of vaccines for developing countries or for pandemic vaccines where long term storage under refrigerated conditions is a major issue. Additionally, due to the versatility of the approach facilitates straightforward co-encapsulation of a wide variety of additional components to further modulate the immune response.
机译：基于中性聚合物和单宁酸之间的氢键，纳米孔微粒可一步完成。这些颗粒在生理介质中稳定，对体外培养的细胞无毒，可以有效地包裹蛋白质。体外和体内实验表明，这些多孔的氢键结合的微粒能够诱导针对封装疫苗抗原的抗原特异性细胞和体液免疫应答。考虑到由批准的现成成分可轻松，低成本地生产这种干粉制剂，预计该技术对于发展中国家或大流行疫苗（在冷藏条件下长期储存是主要问题）的大剂量疫苗制剂具有广阔的前景。另外，由于该方法的多功能性，有助于多种其他成分的直接共包封，以进一步调节免疫反应。

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  • 来源
    《Advanced Functional Materials》 |2014年第29期|4634-4644|共11页
  • 作者

    Marijke Dierendonck; Kaat Fierens; Riet De Rycke; Lien Lybaert; Samarendra Maji; Zhiyue Zhang; Qilu Zhang; Richard Hoogenboom; Bart N. Lambrecht; Johan Grooten; Jean Paul Remon; Stefaan De Koker; Bruno G. De Geest;

  • 作者单位

    Department of Pharmaceutics Ghent University 9000, Ghent, Belgium;

    VIB Inflammation Research Center 9052 Zwijnaarde, Belgium,Department of Respiratory Medicine Ghent University 9000 Ghent, Belgium;

    VIB Inflammation Research Center 9052 Zwijnaarde, Belgium;

    Department of Pharmaceutics Ghent University 9000, Ghent, Belgium;

    Supramoiecular Chemistry Group Department of Organic Chemistry Ghent University 9000 Ghent, Belgium;

    Department of Pharmaceutics Ghent University 9000, Ghent, Belgium;

    Supramoiecular Chemistry Group Department of Organic Chemistry Ghent University 9000 Ghent, Belgium;

    Supramoiecular Chemistry Group Department of Organic Chemistry Ghent University 9000 Ghent, Belgium;

    VIB Inflammation Research Center 9052 Zwijnaarde, Belgium,Department of Respiratory Medicine Ghent University 9000 Ghent, Belgium;

    Department of Biomedical Molecular Biology Ghent University 9052 Zwijnaarde, Belgium;

    Department of Pharmaceutics Ghent University 9000, Ghent, Belgium;

    Department of Biomedical Molecular Biology Ghent University 9052 Zwijnaarde, Belgium;

    Department of Pharmaceutics Ghent University 9000, Ghent, Belgium;

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