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首页> 外文期刊>Advanced Functional Materials >Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo
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Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo

机译：具有高度生物相容性的碳纳米点，可在体内和体外同时进行生物成像和靶向光动力疗法

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摘要

Photosensitizers (PSs) are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for targeted photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, a novel design is described of highly biocompatible, fluorescent, folic acid (FA)-functionalized carbon nanodots (CDs) as carriers for the PS zinc phthalocyanine (ZnPc) to achieve simultaneous biological imaging and targeted photodynamic therapy. FA is modified on PEG-passivated CDs (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is loaded onto CD-PEG-FA via π-π stacking interactions. CD-PEG-FA/ZnPc exhibits excellent targeted delivery of the PS, leading to simultaneous imaging and significant targeted photodynamic therapy after irradiation in vitro and in vivo. The present CD-based targeted delivery of PSs is anticipated to offer a convenient and effective platform for enhanced photodynamic therapy to treat cancers in the near future.
机译：光敏剂（PSs）是高度疏水的光敏分子，这给其用于靶向光动力疗法带来了挑战。因此，已经做出了巨大的努力来开发用于PS的递送的载体。本文中，描述了一种新的设计，该设计具有高度生物相容性，荧光，叶酸（FA）-官能化的碳纳米点（CD）作为PS锌酞菁（ZnPc）的载体，以实现同时的生物成像和靶向光动力疗法。将FA修饰在PEG钝化CD（CD-PEG）上，以靶向递送至FA阳性癌细胞，并且ZnPc通过π-π堆积相互作用加载到CD-PEG-FA上。 CD-PEG-FA / ZnPc表现出优异的PS靶向递送，在体外和体内照射后可同时进行成像和显着的靶向光动力疗法。预期在不久的将来，目前基于CD的PS靶向递送将为增强的光动力疗法提供一种方便有效的平台，以治疗癌症。

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  • 来源
    《Advanced Functional Materials》 |2014年第37期|5781-5789|共9页
  • 作者

    Yuri Choi; Seongchan Kim; Myung-Ho Choi; Soo-Ryoon Ryoo; Jongnam Park; Dal-Hee Min; Byeong-Su Kim;

  • 作者单位

    Department of Chemistry and Department of Energy Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798, Korea;

    Department of Chemistry Seoul National University Center for RNA Research Institute for Basic Science (IBS) Seoul 151-744, Korea;

    Department of Chemistry Seoul National University Center for RNA Research Institute for Basic Science (IBS) Seoul 151-744, Korea;

    Department of Chemistry Seoul National University Center for RNA Research Institute for Basic Science (IBS) Seoul 151-744, Korea;

    Department of Chemistry and Department of Energy Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798, Korea;

    Department of Chemistry Seoul National University Center for RNA Research Institute for Basic Science (IBS) Seoul 151-744, Korea;

    Department of Chemistry and Department of Energy Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798, Korea;

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