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Hybrid Organic-Inorganic Biosensor for Ammonia Operating under Harsh Physiological Conditions

机译：严苛生理条件下用于氨的混合有机-无机生物传感器

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摘要

A biosensor for ammonia is developed aimed at detecting the presence of H. pylori bacteria in gastric fluids. The sensor is based on a GaAs device coated with a unique functional polymer that enables high device sensitivity to low concentrations of ammonia and long-term protection in harsh environments. The detection of ammonia in gastric fluids taken from patients is possible by covering the device with a dialysis membrane, thus enabling the diffusion of only small molecules to the sensing area, while preventing agglomeration of macromolecules on the surface of the device. The mechanism by which ammonia is detected is investigated and an analytical expression is provided relating the response of the detector to the ammonia concentration and the pH of the solution.
机译：开发了一种氨生物传感器，旨在检测胃液中是否存在幽门螺杆菌。该传感器基于涂有独特功能性聚合物的GaAs器件，该器件可实现对低浓度氨的高器件敏感性，并在恶劣环境中提供长期保护。通过用透析膜覆盖该设备，可以检测从患者身上获取的胃液中的氨，从而仅允许小分子扩散到传感区域，同时防止大分子在设备表面凝聚。研究了检测氨的机理，并提供了将检测器的响应与氨浓度和溶液pH值联系起来的解析表达式。

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  • 来源
    《Advanced Functional Materials》 |2014年第37期|5833-5840|共8页
  • 作者

    Tatikonda Anand Kumar; Eyal Capua; Maria Tkachev; Samuel N. Adler; Ron Naaman;

  • 作者单位

    Department of Chemical Physics The Weizmann Institute of Science Rehovot 76100, Israel;

    Department of Chemical Physics The Weizmann Institute of Science Rehovot 76100, Israel;

    Department of Chemical Physics The Weizmann Institute of Science Rehovot 76100, Israel;

    Department of Gastroenterology Shaare Zedek Medical Center Jerusalem, Israel;

    Department of Chemical Physics The Weizmann Institute of Science Rehovot 76100, Israel;

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