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All-Natural Oil-Filled Microcapsules from Water-Insoluble Proteins

机译:水不溶性蛋白质的全天然油填充微胶囊

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摘要

The formation and characterization of a novel class of all-natural digestible microcapsules containing a liquid lipid core encapsulated by a water-insoluble protein shell with tunable thickness is demonstrated. As an example of a water-insoluble protein, zein is used-the protein of corn-which is an attractive biomaterial from a sustainable source. The microcapsules are prepared by a direct and simple method, based on the precipitation of protein from the continuous phase of an oil-in-(water/ethanol) emulsion onto the oil droplets without the need of any surfactant. The shell thickness can be controlled by the amount of precipitated protein. An in vitro digestion assay is performed to study the lipid hydrolysis and biodegradability. The rate of lipid hydrolysis and release of fatty acids are highly dependent on the protein shell thickness. All-natural edible microcapsules with controlled degradation under gastrointestinal conditions can enable new applications for oral delivery systems. They may further be used as a model system for controlled release studies of lipophilic compounds and could promote the sustainable use of underutilized water insoluble proteins as functional biomaterials.
机译:新型的全天然可消化微囊的形成和表征,其包含被厚度可调的水不溶性蛋白壳包裹的液态脂质核。作为水不溶性蛋白质的一个例子,玉米醇溶蛋白被用作玉米蛋白,它是一种来自可持续来源的有吸引力的生物材料。通过直接和简单的方法来制备微胶囊,其基于蛋白质从水包油(水/乙醇)乳液的连续相到油滴上的沉淀而无需任何表面活性剂。壳的厚度可以通过沉淀的蛋白质的量来控制。进行体外消化测定以研究脂质水解和生物降解性。脂质水解和脂肪酸释放的速率高度依赖于蛋白质壳的厚度。在胃肠道条件下具有可控降解的全天然食用微胶囊可以为口服给药系统带来新的应用。它们还可以用作亲脂性化合物控释研究的模型系统,并可以促进未充分利用的水不溶性蛋白质作为功能性生物材料的可持续利用。

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  • 来源
    《Advanced Functional Materials》 |2014年第38期|5962-5968|共7页
  • 作者单位

    Unilever R&D Vlaardingen Olivier van Noortlaan 120, Vlaardingen, The Netherlands,Materials Research Laboratory, University of California, Santa Barbara, CA 93106 USA,Center for Soft Matter Research Department of Physics New York University New York, NY 10003, USA;

    Unilever R&D Vlaardingen Olivier van Noortlaan 120, Vlaardingen, The Netherlands,Vandemoortele Centre for Lipid Science and Technology, Univ. of Gent, Coupure Links 653, B-9000 Gent, Belgium;

    Unilever R&D Vlaardingen Olivier van Noortlaan 120, Vlaardingen, The Netherlands;

    Unilever R&D Vlaardingen Olivier van Noortlaan 120, Vlaardingen, The Netherlands;

    Unilever R&D Vlaardingen Olivier van Noortlaan 120, Vlaardingen, The Netherlands,Soft Condensed Matter Group Debye Institute for NanoMaterials Science Utrecht University Princetonplein 5 3584 CC, Utrecht, The Netherlands;

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