• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Engineering of Multifunctional Nano-Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging
【24h】

Engineering of Multifunctional Nano-Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging

机译：多模态成像指导下的多功能纳米胶束光热与光动力联合治疗工程

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The integration of diagnostic and therapeutic functionalities on a single thera-nostic nano-system holds great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy. Herein, a multifunctional polymeric nano-micelle system that contains a photosensitizer chlorin e6 (Ce6) is successfully fabricated, at the same time serving as a chelating agent for Cd~(3+), together with a near-infrared (NIR) dye, IR825. With a r_1 relativity 7 times higher than that of the commercial agent Magnevist, strong fluorescence offered by Ce6, and high NIR absorbance attributed to IR825, these thera-nostic micelles can be utilized as a contrast agent for triple modal magnetic resonance (MR), fluorescence, and photoacoustic imaging of tumors in a mouse model. The combined photothermal and photodynamic therapy is then carried out, achieving a synergistic anti-tumor effect both in vitro and in vivo. Different from single photo treatment modalities which only affect the superficial region of the tumor under mild doses, the combination therapy at the same dose using this agent is able to induce significant damage to both superficial and deep parts of the tumor. Therefore, this work presents a polymer based theranostic platform with great potential in multimodal imaging and combination therapy of cancer.
机译：将诊断和治疗功能集成在单个治疗纳米系统上，有望提高诊断的准确性并提高治疗效果。本文成功制备了包含光敏剂二氢卟酚e6（Ce6）的多功能聚合物纳米胶束系统，同时用作Cd〜（3+）的螯合剂以及近红外（NIR）染料， IR825。这些治疗胶束的r_1相对于商品代理Magnevist的相对论性高7倍，Ce6提供强荧光，IR825具有很高的近红外吸收率，可以用作三模态磁共振（MR）的造影剂，小鼠模型中的肿瘤的荧光和光声成像。然后进行光热和光动力疗法的组合，在体外和体内均达到协同的抗肿瘤作用。与仅在轻度剂量下仅影响肿瘤浅表区域的单次光疗方式不同，使用该药物以相同剂量联合治疗能够对肿瘤的浅表和深部造成明显损害。因此，这项工作提出了一种基于聚合物的治疗学平台，在癌症的多峰成像和联合治疗中具有巨大的潜力。

著录项

  • 来源
    《Advanced Functional Materials》 |2014年第41期|6492-6502|共11页
  • 作者

    Hua Gong; Ziliang Dong; Yumeng Liu; Shengnan Yin; Liang Cheng; Wenyao Xi; Jian Xiang; Kai Liu; Yonggang Li; Zhuang Liu;

  • 作者单位

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China;

    Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

    Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China;

    Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou, Jiangsu 215123, China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号