• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Multimodal Magneto-Plasmomc Nanoclusters for Biomedical Applications
【24h】

Multimodal Magneto-Plasmomc Nanoclusters for Biomedical Applications

机译：用于生物医学应用的多峰磁-等离子体纳米簇

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Multimodal nanostructures can help solve many problems in the biomedical field including sensitive molecular imaging, highly specific therapy, and early cancer detection. However, the synthesis of densely packed, multicomponent nanostructures with multimodal functionality represents a significant challenge. Here, a new type of hybrid magneto-plasmonic nanoparticles is developed using an oil-in-water microemulsion method. The nanostructures are synthetized by self-assembly of primary 6 nm iron oxide core-gold shell particles resulting into densely packed spherical nanoclusters. The dense packing of primary particles does not change their superparamagnetic behavior; however, the close proximity of the constituent particles in the nanocluster leads to strong near-infrared (NIR) plasmon resonances. The synthesis is optimized to eliminate nanocluster cytotoxicity. Immunotargeted nanoclusters are also developed using directional conjugation chemistry through the Fc antibody moiety, leaving the Fab antigen recognizing region available for targeting. Cancer cells labeled with immunotargeted nanoclusters produce a strong photoacoustic signal in the NIR that is optimum for tissue imaging. Furthermore, the labeled cells can be efficiently captured using an external magnetic field. The biocompatible magneto-plasmonic nanoparticles can make a significant impact in development of point-of-care assays for detection of circulating tumor cells, as well as in cell therapy with magnetic cell guidance and imaging monitoring.
机译：多峰纳米结构可以帮助解决生物医学领域的许多问题，包括敏感的分子成像，高度特异性的治疗方法和早期癌症检测。然而，具有多峰功能性的紧密堆积的多组分纳米结构的合成代表了巨大的挑战。在这里，使用水包油微乳液方法开发了一种新型的杂化磁等离子体纳米颗粒。纳米结构是通过自组装6纳米氧化铁核-金壳粒子的自组装而合成的，从而形成紧密堆积的球形纳米团簇。初级粒子的致密堆积不会改变其超顺磁性行为。然而，纳米团簇中组成颗粒的紧密接近导致强烈的近红外（NIR）等离子体激元共振。优化合成以消除纳米簇的细胞毒性。还通过定向缀合化学通过Fc抗体部分开发了免疫靶向的纳米簇，使Fab抗原识别区可用于靶向。标记有免疫靶向纳米簇的癌细胞会在NIR中产生强烈的光声信号，这对于组织成像是最佳的。此外，可以使用外部磁场有效地捕获标记的细胞。具有生物相容性的磁等离子体纳米颗粒可以在用于检测循环肿瘤细胞的即时检测方法的开发中，以及在具有磁性细胞指导和成像监控功能的细胞治疗中，产生重大影响。

著录项

  • 来源
    《Advanced Functional Materials》 |2014年第43期|6862-6871|共10页
  • 作者

    Chun-Hsien Wu; Jason Cook; Stanislav Emelianov; Konstantin Sokolov;

  • 作者单位

    Department of Biomedical Engineering University of Texas at Austin Austin, TX, 78712, USA,Department of Imaging Physics University of Texas M.D. Anderson Cancer Center Houston, TX, 77030, USA;

    Department of Biomedical Engineering University of Texas at Austin Austin, TX, 78712, USA;

    Department of Biomedical Engineering University of Texas at Austin Austin, TX, 78712, USA;

    Department of Biomedical Engineering University of Texas at Austin Austin, TX, 78712, USA,Department of Imaging Physics University of Texas M.D. Anderson Cancer Center Houston, TX, 77030, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号