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首页> 外文期刊>Advanced Functional Materials >Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control
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Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control

机译：多功能上转换纳米粒子在远程磁控制下用于双模态成像引导干细胞治疗

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摘要

Stem cells have generated a great deal of excitement in cell-based therapies. Here, a unique class of multifunctional nanoparticles (MFNPs) with both upconversion luminescence (UCL) and superparamagnetic properties is used for stem cell research. It is discovered that after being labeled with MFNPs, mouse mesenchymal stem cells (mMSCs) are able to maintain their viability and differentiation ability. In vivo UCL imaging of MFNP-labeled mMSCs transplanted into animals is carried out, achieving ultrahigh tracking sensitivity with a detection limit as low as ≈10 cells in a mouse. Using both UCL optical and magnetic resonance (MR) imaging approaches, MFNP-labeled mMSCs are tracked after being intraperitoneally injected into wound-bearing mice under a magnetic field. The translocation of mMSCs from the injection site to the wound nearby the magnet is observed and, intriguingly, a remarkably improved tissue repair effect is observed as the result of magnetically induced accumulation of stem cells in the wound site. The results demonstrate the use MFNPs as novel multifunctional probes for labeling, in vivo tracking, and manipulation of stem cells, which is promising for imaging guided cell therapies and tissue engineering.
机译：干细胞在基于细胞的疗法中引起了极大的兴奋。在这里，一类独特的同时具有上转换发光（UCL）和超顺磁性的多功能纳米颗粒（MFNP）用于干细胞研究。发现用MFNPs标记后，小鼠间充质干细胞（mMSCs）能够维持其生存能力和分化能力。对移植到动物中的MFNP标记的mMSC进行了体内UCL成像，实现了超高跟踪灵敏度，在小鼠中的检测限低至≈10个细胞。使用UCL光学和磁共振（MR）成像方法，在磁场下将MFNP标记的mMSC腹膜内注射到带有伤口的小鼠中后，可以对其进行跟踪。观察到mMSC从注射部位向磁体附近的伤口移位，并且有趣的是，由于磁诱导的干细胞在伤口部位的积累，观察到显着改善的组织修复效果。结果表明，MFNPs作为新型多功能探针可用于标记，体内追踪和操纵干细胞，这有望在成像指导的细胞疗法和组织工程学中获得应用。

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  • 来源
    《Advanced Functional Materials》 |2013年第3期|272-280|共9页
  • 作者

    Liang Cheng; Chao Wang; Xinxing Ma; Qinglong Wang; Yao Cheng; Han Wang; Yonggang Li; Zhuang Liu;

  • 作者单位

    Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano&Soft Materials Laboratory (FUNSOM) Soochow University Suzhou, Jiangsu 215123, China;

    Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano&Soft Materials Laboratory (FUNSOM) Soochow University Suzhou, Jiangsu 215123, China;

    Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215123, China;

    Laboratory of Developmental Genetics and Genomics Medical College Soochow University Suzhou 215123, China;

    Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano&Soft Materials Laboratory (FUNSOM) Soochow University Suzhou, Jiangsu 215123, China;

    Laboratory of Developmental Genetics and Genomics Medical College Soochow University Suzhou 215123, China;

    Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215123, China;

    Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano&Soft Materials Laboratory (FUNSOM) Soochow University Suzhou, Jiangsu 215123, China;

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