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Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation

机译：用于干细胞分化的模块化多功能聚乙二醇水凝胶

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摘要

Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biologlcal or chemical ligands, which often changes the fundamental structural properties of the material. Here, a simple modular biomaterial design strategy is reported that employs functional cyclodextrin nanobeads threaded onto poly(ethylene giycol) (PEC) polymer necklaces to form multifunctional hydro-gels. Nanobeads with desired chemical or biological functionalities can be simply threaded onto the PEG chains to form hydrogels, creating an accessible platform for users. The design and synthesis of these multifunctional hydrogels are described, structure-property relationships are elucidated, and applications ranging from stem cell culture and differentiation to tissue engineering are demonstrated.
机译：合成聚合物用于创建具有受控的生化和生物物理特性的高定义微环境，用于细胞培养和组织工程。输入生物逻辑或化学配体需要化学修饰，这通常会改变材料的基本结构特性。在这里，报告了一种简单的模块化生物材料设计策略，该策略采用将功能性环糊精纳米珠穿入聚（乙二醇）（PEC）聚合物项链上以形成多功能水凝胶的方法。具有所需化学或生物学功能的纳米珠可以简单地穿入PEG链上以形成水凝胶，为用户提供可访问的平台。描述了这些多功能水凝胶的设计和合成，阐明了结构与性质的关系，并论证了从干细胞培养，分化到组织工程的各种应用。

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  • 来源
    《Advanced Functional Materials》 |2013年第5期|575-582|共8页
  • 作者

    Anirudha Singh; Jianan Zhan; Zhaoyang Ye; Jennifer H. Elisseeff;

  • 作者单位

    Wilmer Eye Institute & Department of Biomedical Engineering 400 N, Broadway, Robert H. & Clarice Smith Building Johns Hopkins University Baltimore, MD 21231, USA;

    Wilmer Eye Institute & Department of Biomedical Engineering 400 N, Broadway, Robert H. & Clarice Smith Building Johns Hopkins University Baltimore, MD 21231, USA;

    The State Key Laboratory of Bioreactor Engineering School of Bioengineering,East China University of Science and Technology Shanghai-200237, China;

    Wilmer Eye Institute & Department of Biomedical Engineering 400 N, Broadway, Robert H. & Clarice Smith Building Johns Hopkins University Baltimore, MD 21231, USA;

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