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Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy

机译：金纳米壳Nanomicelles用于潜在的磁共振成像，光触发药物释放和光热疗法

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摘要

A novel multifunctional drug-delivery platform is developed based on cholesteryl succinyl silane (CSS) nanomicelles loaded with doxorubicin, Fe_3O_4 magnetic nanoparticles, and gold nanoshells (CDF-Au-shell nanomicelles) to combine magnetic resonance (MR) imaging, magnetic-targeted drug delivery, light-triggered drug release, and photothermal therapy. The nanomicelles show improved drug-encapsulation efficiency and loading level, and a good response to magnetic fields, even after the formation of the gold nanoshell. An enhancement for T_2-weighted MR imaging is observed for the CDF-Au-shell nanomicelles. These nanomicelles display surface plasmon absorbance in the near-infrared (NIR) region, thus exhibiting an NIR (808 nm)-induced temperature elevation and an NIR light-triggered and stepwise release behavior of doxorubicin due to the unique characteristics of the CSS nanomicelles. Photothermal cytotoxicity in vitro confirms that the CDF-Au-shell nanomicelles cause cell death through photothermal effects only under NIR laser irradiation. Cancer cells incubated with CDF-Au-shell nanomicelles show a significant decrease in cell viability only in the presence of both NIR irradiation and a magnetic field, which is attributed to the synergetic effects of the magnetic-field-guided drug delivery and the photothermal therapy. Therefore, such multicom-ponent nanomicelles can be developed as a smart and promising nano-system that integrates multiple capabilities for effective cancer diagnosis and therapy.
机译：基于载有阿霉素，Fe_3O_4磁性纳米颗粒和金纳米壳（CDF-Au壳纳米颗粒）的胆固醇基琥珀酰硅烷（CSS）纳米胶束开发了一种新型的多功能药物递送平台，以结合磁共振（MR）成像，磁靶向药物递送，光触发药物释放和光热疗法。即使在金纳米壳形成之后，纳米胶束也显示出改善的药物包封效率和负载水平，并且对磁场具有良好的响应。对于CDF-Au-壳纳米胶束，观察到了T_2加权MR成像的增强。这些纳米胶束在近红外（NIR）区域显示表面等离激元吸收，因此由于CSS纳米胶束的独特特性，显示出NIR（808 nm）引起的温度升高以及阿霉素的NIR光触发和逐步释放行为。体外光热细胞毒性证实，CDF-Au-壳纳米胶束仅在近红外激光照射下才通过光热效应引起细胞死亡。与CDF-Au壳纳米胶束一起孵育的癌细胞仅在同时存在NIR辐射和磁场的情况下才显示细胞活力的显着降低，这归因于磁场引导的药物递送和光热疗法的协同作用。因此，可以将这种多组分纳米胶束开发为一种智能且有前途的纳米系统，该系统集成了多种功能，可进行有效的癌症诊断和治疗。

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  • 来源
    《Advanced Functional Materials》 |2013年第7期|815-822|共8页
  • 作者

    Yan Ma; Xiaolong Liang; Sheng Tong; Gang Bao; Qiushi Ren; Zhifei Dai;

  • 作者单位

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin, 150080, China;

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, China;

    Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta, GA 30332, USA;

    Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta, GA 30332, USA;

    Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, China;

    Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology Harbin, 150080, China,Department of Biomedical Engneering College of Engineering Peking University Beijing 100871, China;

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