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A Stiff Injectable Biodegradable Elastomer

机译:硬质可注射生物降解弹性体

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摘要

In jectable materials often have shortcomings in mechanical and drug-eluting properties that are attributable to their high water contents. A water-free, liquid four-armed PEC modified with dopamine end groups is described which changes from liquid to elastic solid by reaction with a small volume of Fe~(3+) solution. The elastic modulus and degradation times increase with increasing Fe~(3+) concentrations. Both the free base and the water-soluble form of lidocaine can be dissolved in the PEG_4-dopamine and released in a sustained manner from the cross-linked matrix. PEG_4-dopamine is retained in the subcutaneous space in vivo for up to 3 weeks with minimal inflammation. This material's tailorable mechanical properties, biocompatibility, ability to incorporate hydrophilic and hydrophobic drugs and release them slowly are desirable traits for drug delivery and other biomedical applications.
机译:在可注射材料中,由于其高水含量,通常在机械和药物洗脱性能方面存在缺陷。描述了一种用多巴胺端基改性的无水液态四臂PEC,它通过与少量Fe〜(3+)溶液反应而从液态变为弹性固体。随着Fe〜(3+)浓度的增加,弹性模量和降解时间增加。利多卡因的游离碱和水溶性形式都可以溶解在PEG_4-多巴胺中,并以持续的方式从交联的基质中释放出来。 PEG_4-多巴胺在体内的皮下空间最多可保留3周,而炎症最小。这种材料的可定制机械性能,生物相容性,结合亲水性和疏水性药物并缓慢释放的能力是药物递送和其他生物医学应用的理想特性。

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  • 来源
    《Advanced Functional Materials》 |2013年第12期|1527-1533|共7页
  • 作者单位

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA,Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA,Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA,Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA,Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Department of Chemical Engineering Division of Health Science and Technology David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139, USA;

    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue, Boston, MA 02115, USA;

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