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首页> 外文期刊>Advanced Functional Materials >MnO Nanocrystals: A Platform for Integration of MRI and Genuine Autophagy Induction for Chemotherapy
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MnO Nanocrystals: A Platform for Integration of MRI and Genuine Autophagy Induction for Chemotherapy

机译：MnO纳米晶体：整合MRI和真正的自噬诱导化学疗法的平台。

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摘要

Herein, a kind of novel monocomponent hydrophilic and paramagnetic manganese(II) oxide nanocrystal is prepared in polar solution by a one-pot microwave-assisted synthesis. This kind of nanocrystal can be taken up efficiently to serve as an excellent T_1 magnetic resonance imaging (MRI) contrast agent with an enhanced r_1 value of 0.81 mM~(-1) s~(-1). The key to the success of this method is that no additional capping agents are required for coating onto the surface via ligand exchange, facilitating research of their intrinsic biological activities. Furthermore, multiple lines of convincing evidence are presented to prove that MnO nanocrystals (NCs) elicit p53-activation-independent and authentic functional autophagy via inducing autophago-some formation. Notably, there are very few reports so far of the autophagy phenomenon induced by magnetic nanocrystals. Moreover, these results offer an indication for cancer therapy that MnO NCs combined with doxorubicin at a nontoxic concentration can have a definite synergistic effect, which is mediated through the genuine autophagy induction, on killing cancer cells in vitro and in vivo.
机译：本文通过一锅微波辅助合成法在极性溶液中制备了一种新型的单组分亲水性顺磁性锰（II）氧化物纳米晶。可以有效地吸收这种纳米晶体，用作具有出色的r_1值0.81 mM〜（-1）s〜（-1）的T_1磁共振成像（MRI）造影剂。该方法成功的关键是不需要通过配体交换将额外的封端剂涂在表面上，从而有助于对其内在生物学活性的研究。此外，提供了多条令人信服的证据来证明MnO纳米晶体（NCs）通过诱导自噬小体的形成引起p53活化独立和真实的功能自噬。值得注意的是，迄今为止，关于磁性纳米晶体引起的自噬现象的报道很少。此外，这些结果为癌症治疗提供了一个指示，即无毒浓度的MnO NCs与阿霉素联用可对体外和体内杀死癌细胞具有确定的协同作用，这是通过真正的自噬诱导来介导的。

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  • 来源
    《Advanced Functional Materials》 |2013年第12期|1534-1546|共13页
  • 作者

    Yang Lu; Li Zhang; Jing Li; Yu-De Su; Yun Liu; Yun-Jun Xu; Liang Dong; Huai-Ling Cao; Jun Lin; Na Man; Peng-Fei Wei; Wei-Ping Xu; Shu-Hong Yu; Long-Ping Wen;

  • 作者单位

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China,Anhui Provincial Hospital Hefei, 230001, P. R.China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

    Anhui Provincial Hospital Hefei, 230001, P. R.China;

    Division of Nanomaterials &, Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemistry CAS Key Laboratory of Mechanical Behavior and Design of Materials the National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026, P. R. China;

    Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei 230027, P. R. China;

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