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首页> 外文期刊>Advanced Functional Materials >Electrospun Fibers as a Solid-State Real-Time Zinc Ion Sensor with High Sensitivity and Cell Medium Compatibility
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Electrospun Fibers as a Solid-State Real-Time Zinc Ion Sensor with High Sensitivity and Cell Medium Compatibility

机译：电纺纤维作为具有高灵敏度和细胞介质兼容性的固态实时锌离子传感器

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摘要

meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl_2), a probe molecule for zinc II ions, is dispersed in a polymer host. The red fluorescence peak at 620 nm appears when the molecule forms a complex with zinc at its center. TPN-Cl_2 has a high selectivity for zinc II and tolerates many common metal ions present in the human body. The probe molecules are blended with a hydrogel polymer, poly(2-hydroxyethyl methacrylate) (poly HEMA), with 30 wt% dimethylformamide (DMF). The fiber structure with 1 μm diameter is made by electrospinning in DMF solution of the probe and poly HEMA mixture. The fibrous film detects zinc ions with concentrations as low as 10~(-6) M in real-time both in water and in the commonly used cell culture liquid media Dulbecco's modified Eagle medium (DMEM) and fetal bovine serum (FBS), which contain many metal ions and proteins. The time-resolution is 5 min for 10~(-6) M and 1 min for 10~(-5) M. This sensitivity and response speed satisfy the requirements for non-invasive biomedical studies.
机译：Meso-2,6-Dichlorophenyltripyrrinone（TPN-Cl_2），一种用于锌II离子的探针分子，分散在聚合物主体中。当分子在中心与锌形成络合物时，在620 nm处出现红色荧光峰。 TPN-Cl_2对锌II具有很高的选择性，并能耐受人体中存在的许多常见金属离子。将探针分子与具有30 wt％的二甲基甲酰胺（DMF）的水凝胶聚合物，聚（甲基丙烯酸2-羟乙酯）（poly HEMA）混合。直径为1μm的纤维结构是通过在探针和聚HEMA混合物的DMF溶液中进行电纺而制成的。纤维膜可实时检测水中和常用细胞培养液培养基中Dulbecco改良的Eagle培养基（DMEM）和胎牛血清（FBS）中浓度低至10〜（-6）M的锌离子。包含许多金属离子和蛋白质。 10〜（-6）M的时间分辨率为5分钟，而10〜（-5）M的时间分辨率为1分钟。这种灵敏度和响应速度满足了非侵入性生物医学研究的要求。

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  • 来源
    《Advanced Functional Materials》 |2013年第12期|1566-1574|共9页
  • 作者

    Jia-Hao Syu; Yi-Kai Cheng; Wun-Yan Hong; Hsing-Ping Wang; Yu-Chao Lin; Hsin-Fei Meng; Hsiao-Wen Zan; Sheng-Fu Horng; Gao-Fong Chang; Chen-Hsiung Hung; Yu-Cheng Chiu; Wen-Chang Chen; May-Jywan Tsai; Henrich Cheng;

  • 作者单位

    Department of Electrical Engineering National Tsing Hua University Hsinchu 300, Taiwan, Republic of China;

    Department of Electrical Engineering National Tsing Hua University Hsinchu 300, Taiwan, Republic of China;

    Department of Electrical Engineering National Tsing Hua University Hsinchu 300, Taiwan, Republic of China;

    Institute of Physics National Chiao Tung University Hsinchu 300, Taiwan, Republic of China;

    Department of Electrical Engineering National Tsing Hua University Hsinchu 300, Taiwan, Republic of China;

    Institute of Physics National Chiao Tung University Hsinchu 300, Taiwan, Republic of China;

    Department of Photonics and the Institute of Electro-Optical Engineering National Chiao Tung University Hsinchu 300, Taiwan, Republic of China;

    Department of Electrical Engineering National Tsing Hua University Hsinchu 300, Taiwan, Republic of China;

    Institute of Chemistry Academia Sinica, Taipei 115, Taiwan, Republic of China;

    Institute of Chemistry Academia Sinica, Taipei 115, Taiwan, Republic of China;

    Department of Chemical Engineering National Taiwan University Taipei 106, Taiwan, Republic of China;

    Department of Chemical Engineering National Taiwan University Taipei 106, Taiwan, Republic of China;

    Neural Regeneration Laboratory and Center for Neural Regeneration Department of Neurosurgery Neurological Institute;

    Neural Regeneration Laboratory and Center for Neural Regeneration Department of Neurosurgery Neurological Institute;

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