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首页> 外文期刊>Advanced Functional Materials >A Near-Infrared Light-Triggered Nanocarrier with Reversible DNA Valves for Intracellular Controlled Release
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A Near-Infrared Light-Triggered Nanocarrier with Reversible DNA Valves for Intracellular Controlled Release

机译：具有可逆DNA阀的近红外光触发纳米载体用于细胞内控释

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摘要

A near-infrared (NIR) light-triggered nanocarrier is developed for intracellular controlled release with good stability, high nuclease resistance, and good biocompatibility. The nanocarrier consists of a gold nanorod core and mes-oporous silica shell, capped with reversible single-stranded DNA valves, which are manipulated by switching between the laser on/off states. Upon laser irradiation, the valves of the nanocarrier open and the cargo molecules can be released from the mesopores. When the NIR laser is turned off, the valves close and the nanocarrier stops releasing the cargo molecules. The release amount of the cargo molecules can be controlled precisely by adjusting the irradiation time and the laser on-off cycles. Confocal fluorescence imaging shows that the nanocarrier can be triggered by the laser irradiation and the controlled release can be accomplished in living cells. Moreover, the therapeutic effect toward cancer cells can also be regulated when the chemotherapeutic drug doxorubicin is loaded into the nanocarrier. This novel approach provides an ideal platform for drug delivery by a NIR light-activated mechanism with precise control of area, time, and especially dosage.
机译：开发了一种近红外（NIR）触发的纳米载体，用于细胞内控释，具有良好的稳定性，高核酸酶抗性和良好的生物相容性。纳米载体由金纳米棒核和中孔二氧化硅壳组成，上面盖有可逆的单链DNA阀，可通过在激光的开/关状态之间进行切换来对其进行操作。在激光照射下，纳米载体的阀打开，并且货物分子可以从中孔释放。当近红外激光关闭时，阀门关闭，纳米载体停止释放货物分子。货物分子的释放量可以通过调节照射时间和激光开-关周期来精确控制。共聚焦荧光成像表明，纳米载体可以被激光照射触发，并且可以在活细胞中完成控制释放。此外，当将化疗药物阿霉素加载到纳米载体中时，还可以调节对癌细胞的治疗效果。这种新颖的方法通过NIR光激活机制提供了理想的药物递送平台，并精确控制了面积，时间，尤其是剂量。

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  • 来源
    《Advanced Functional Materials》 |2013年第18期|2255-2262|共8页
  • 作者

    Na Li; Zhengze Yu; Wei Pan; Yaoyao Han; Tingling Zhang; Bo Tang;

  • 作者单位

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

    College of Chemistry Chemical Engineering and Materials Science Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Ministry of Education Key Laboratory of Molecular and Nano Probes Ministry of Education Shandong Normal University Jinan 250014, P. R. China;

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