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Remote-Controlled Hydrogel Depots for Time-Scheduled Vaccination

机译：定时接种疫苗的远程控制水凝胶库

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摘要

Remote-controlled drug depots represent a highly valuable tool for the timely controlled administration of Pharmaceuticals in a patient compliant manner. Here, the first pharmacologically controlled material that allows for the scheduled induction of a medical response in mice is described. To this aim, a novel, humanized biohybrid material that releases its cargo in response to a small-molecule stimulus licensed for human use is developed. The functionality of the material in mice is demonstrated by the remote-controlled delivery of a vaccine against the oncogenic human papillomavirus type 16. It is shown that the biohybrid depot-mediated immunoprotection is equivalent to the classical multi-injection-based vaccination. These results indicate that this material can be used as a universal remote-controlled vehicle for the patient-compliant delivery of vaccines and pharmaceuticals.
机译：远程控制的药品仓库代表了一种非常有价值的工具，可以按患者的方式及时控制药品的使用。这里，描述了允许在小鼠中有计划地诱导医学反应的第一药理学控制的材料。为此，开发了一种新颖的，人性化的生物杂交材料，该材料可响应许可用于人类的小分子刺激而释放其货物。通过对16种致癌性人类乳头瘤病毒的疫苗的遥控递送，证明了该材料在小鼠中的功能性。研究表明，生物杂种储库介导的免疫保护等同于传统的基于多次注射的疫苗接种。这些结果表明，这种材料可以用作通用的远程控制载体，用于按患者要求运送疫苗和药品。

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  • 来源
    《Advanced Functional Materials》 |2013年第43期|5355-5362|共8页
  • 作者

    Raphael J. Cuebeli; Desiree Hoevermann; Hanna Seitz; Balder Rebmann; Ronald G. Schoenmakers; Martin Ehrbar; Ghislaine Charpin-El Hamri; Marie Daoud-El Baba; Martin Werner; Martin Mueller; Wilfried Weber;

  • 作者单位

    Faculty of Biology SGBM Spemann Graduate School of Biology and Medicine University of Freiburg Albertstrasse 19A, 79104 Freiburg, Germany;

    Faculty of Biology BIOSS Centre for Biological Signalling Studies University of Freiburg Schanzlestrasse 18, 79104 Freiburg, Germany;

    German Cancer Research Center (DKFZ) Im Neuenheimer Feld 242, 69120 Heidelberg, Germany;

    Faculty of Biology BIOSS Centre for Biological Signalling Studies University of Freiburg Schanzlestrasse 18, 79104 Freiburg, Germany;

    Faculty of Biology BIOSS Centre for Biological Signalling Studies University of Freiburg Schanzlestrasse 18, 79104 Freiburg, Germany;

    Department of Obstetrics University Hospital Zurich Frauenklinikstrasse 10, 8091 Zurich, Switzerland;

    Universite de Lyon 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France;

    Universite de Lyon 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France;

    University Medical Center Institute of Pathology University of Freiburg Breisacherstrasse 115A, 79106 Freiburg, Germany;

    German Cancer Research Center (DKFZ) Im Neuenheimer Feld 242, 69120 Heidelberg, Germany;

    Faculty of Biology BIOSS Centre for Biological Signalling Studies University of Freiburg Schanzlestrasse 18, 79104 Freiburg, Germany;

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