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首页> 外文期刊>Advanced Functional Materials >Gold Nanocage-Based Dual Responsive 'Caged Metal Chelator' Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease
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Gold Nanocage-Based Dual Responsive 'Caged Metal Chelator' Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease

机译：基于金纳米笼的双反应“笼中金属螯合剂”释放系统：具有近红外性的无创远程控制，可潜在治疗阿尔茨海默氏病

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摘要

Metal ions have been demonstrated to participate in the pathology of Alzheimer's disease (AD): amyloid-β peptide (Aβ) aggregation and formation of neurotoxic reactive oxygen species (ROS), such as H_2O_2. Metal chelator can block ROS formation and inhibit metal induced Aβ aggregation. Metal-ion chelation therapy as a compelling treatment for AD has been extensively studied. However, most chelators are not suitable for AD treatment because of their poor permeability of the blood-brain barrier and their limited ability to differentiate toxic metals associated with Aβ plaques from those associated with normal metal homeostasis. Here, a novel dual-responsive "caged metal chelator" release system based on gold nanocage (AuNC) for AD treatment is reported. Since arylboronic ester is redox- and thermal-sensitive, phenylboronic acid-functionalized AuNC can serve as an efficient delivery system for H_2O_2-responsive controlled release of metal chelator. The release can be further enhanced through remote control with NIR light because of the high near-infrared absorbance of AuNC. The smart system can effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aα-related toxicity. In light of these advantages, this design provides new insights into noninvasive remote control with NIR to improve therapeutic efficacy for treatment of Alzheimer's disease.
机译：金属离子已被证明参与阿尔茨海默氏病（AD）的病理过程：淀粉样β肽（Aβ）聚集并形成神经毒性活性氧（ROS），例如H_2O_2。金属螯合剂可阻止ROS形成并抑制金属诱导的Aβ聚集。金属离子螯合疗法作为AD的强制疗法已被广泛研究。然而，大多数螯合剂由于其血脑屏障的渗透性差以及区分与Aβ斑块相关的有毒金属与与正常金属稳态相关的有毒金属的能力有限，因此不适合进行AD治疗。在此，报道了一种基于金纳米笼（AuNC）的新型双反应“笼式金属螯合剂”释放系统，用于AD治疗。由于芳基硼酸酯对氧化还原和热敏感，因此苯硼酸官能化的AuNC可以作为H_2O_2响应性金属螯合剂控制释放的有效传递系统。由于AuNC具有很高的近红外吸收率，因此可以通过NIR光进行远程控制来进一步增强释放效果。该智能系统可以有效抑制Aβ聚集物形成，减少细胞ROS，并保护细胞免受Aα相关毒性的影响。鉴于这些优点，该设计为利用NIR进行无创远程控制提供了新的见解，以提高治疗阿尔茨海默氏病的疗效。

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  • 来源
    《Advanced Functional Materials》 |2013年第43期|5412-5419|共8页
  • 作者

    Peng Shi; Meng Li; Jinsong Ren; Xiaogang Qu;

  • 作者单位

    Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Changchun, Jilin 130022, China;

    Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Changchun, Jilin 130022, China;

    Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Changchun, Jilin 130022, China;

    Laboratory of Chemical Biology Division of Biological Inorganic Chemistry State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Changchun, Jilin 130022, China;

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